Daniela Perotti

Daniela Perotti
Fondazione IRCCS Istituto Nazionale Tumori, Italy

PhD, Staff Scientis,

Staff Scientist at the Department of Preventive and Predictive Medicine.


1. P. Radice, D. Perotti, V. De Benedetti, P. Mondini, S. Pilotti, R. Luksch, F. Fossati Bellani, M.A. Pierotti. Allelotyping in Wilms tumors identifies a putative third tumor suppressor gene on chromosome 11. Genomics, 27: 497-501, 1995.

2. M.Miozzo, D.Perotti, F.Minoletti, P.Mondini, S.Pilotti, R.Luksch, F.Fossati-Bellani, M.A.Pierotti, G.Sozzi, P.Radice. Mapping of a putative tumor suppressor locus to proximal 7p in Wilms tumors. Genomics 37, 310-315, 1996

3. A.Ferrari, D.Perotti, R.Giardini, L.Ghio, S.Riva, M.Massimino. Disseminated Burkitt's lymphoma after kidney transplantation: a case report in a boy with Drash syndrome. The Journal of Pediatric Hematology/Oncology 19(2): 151-155, 1997.

4. D. Perotti, P. Mondini, R. Giardini, A. Ferrari, M. Massimino, F. Gambirasio, M. A. Pierotti, F. Fossati-Bellani, P. Radice. No evidence of WT1 involvement in a Burkitt's lymphoma in a patient affected with Denys-Drash syndrome. Annals of Oncology, 9(6): 627-631, 1998.

5. D. Perotti, V. Corletto, R. Giardini, A. Parafioriti, F. Fossati-Bellati, R. Luksch. Retrospective analysis of ploidy in primary osseous and extraosseous Ewing Family Tumors in children. Tumori, 84(4):493-498, 1998.

6. D. Perotti, F. Pettenella, R. Luksch, R. Giardini, F. Gambirasio, D. Ferrari, F. Fossati-Bellani, A. Biondi. Molecular analysis of 1p32 genetic involvement in pediatric T-cell non-Hodgkinn’s lymphoma. Haematologica, 84(2):110-113, 1999.

7. D. Perotti, G. Sozzi, A. Ferrari, M. Casanova, F. Gambirasio, P. Mondini, A. Mezzelani, R. Giardini, F. Pettenella, A. Biondi, F. Fossati-Bellani. Cytogenetic and molecular characterization of a secondary T-cell acute lymphoblastic leukemia in a boy with anaplastic large-cell lymphoma. Haematologica, 84(6):554-557, 1999.

8. D. Perotti, F. Fossati-Bellani, P. Radice. Tumore di Wilms: patologia, sindromi associate, genetica. Riv Ital Pediatr 25:438-445, 1999.

9. D. Perotti, P. Radice. I geni oncosoppressori. Prospettive in Pediatria 2000; 30:147-153

10. Massimino M, Perotti D.,Spreafico F,Luksch R,Garaventa A,Giardini R.Non-ALC peripheral T-cell lymphomas in children: report on two cases and review of the literature. Haematologica. 2000 Oct;85(10):1109-11.

11. Perotti D, Testi MA, Mondini P, Pilotti S, Green ED, Pession A, Sozzi G, Pierotti MA, Fossati-Bellani F, Radice P. Refinement within single yeast artificial chromosome clones of a minimal region commonly deleted on the short arm of chromosome 7 in Wilms tumours. Genes Chromosomes Cancer. 2001 May;31(1):42-7.

12. Luksch R., Perotti D., Cefalo G., Gambacorti Passerini C., Massimino M., Sprafico F., Casanova M., Ferrari A., Terenziani M., Polastri D., Gambirasio F., Podda M., Bozzi F., Parmiani G., Fossti-Bellani F. Immunomodulation in a treatment program including pre- and post-operative interleukin-2 and chemotherapy for childhood osteosarcoma.Tumori. 2003 May-Jun; 89(3):263-8.

13. Terenziani M, Spreafico F, Collini P, Piva L, Perotti D, Podda M, Gandola L, Massimino M, Cereda S, Cefalo G, Luksch R, Casanova M, Ferrari A, Polastri D, Valagussa P, Fossati-Bellani F. Adult Wilms’ tumor: a monoinstitutional experience and a review of the literature. Cancer. 2004 July; 101 (2):289-293.

14. Perotti D,  De Vecchi G, Testi MA, Lualdi E, Modena P, Mondini P, Ravagnani F, Collini P, Di Renzo F, Spreafico F, Terenziani M, Sozzi G, Fossati-Bellani F, Radice P. Germline Mutations of the POU6F2 Gene in Wilms Tumors with Loss of Heterozygosity on Chromosome 7p14. Human Mutation, 2004 November 24 (5): 400-407.

15. Manoukian S, Crolla JA, Palma MA Mammoliti, Testi MA, Zanini R, Carpanelli ML, Piozzi E, Sozzi G, De Vecchi G, Terenziani M, Spreafico F, Collini P, Radice P, Perotti D. Bilateral preaxial polydactyly in a WAGR syndrome patient. Am J Med Genet, 2005 May 134A: 426-429.

16. Perotti D,  Mondini P, Terenziani M, Spreafico F, Collini P, Fossati-Bellani F, Radice P. WT1 gene analysis in sporadic early-onset and bilateral Wilms tumors patients without associated abnormalities. J Pediatr Hematol Oncol, 2005 April 27: 197-201.

17. Perotti D,  De Vecchi G, Lualdi E, Testi MA, Sozzi G, Collini P, Spreafico F, Terenziani M, Fossati-Bellani F, Radice P. Wilms tumor in monozygous twins: clinical, pathological, cytogenetic and molecular case report. J Pediatr Hematol Oncol. 2005 October 27:521-5.

18. Di Renzo F, Doneda L, Menegola E, Sardella M, De Vecchi G, Collini P, Spreafico F, Fossati-Bellani F, Giavini E, Radice P, Perotti D. The murine Pou6f2 gene is temporally and spatially regulated during kidney embryogenesis and its human homolog is overexpressed in a subset of Wilms tumors . J Pediatr Hematol Oncol., 28:791-797, 2006.

19. I.Perotti D., Manoukian S., Radice P. In response to Richard H Scott et al. Electronic letter published, J Med Genet 23 may 2006.

20. Spreafico F,Terenziani M, Lualdi E, Scarfone P, Collini P, Fossati-Bellani F, Galea E, De Vecchi G, Sardella M,  Sozzi G, Radice P, Perotti D. Non Chromosome 11-p Syndromes in Wilms Tumors Patients: Clinical and Cytogenetic Report of two Down Syndrome Cases and one Turner Syndrome Case. Am J Med Genet, 143: 85-88, 2007.

21. Uccini S., Perotti D.**, Colarossi C., Stoppacciaro A., Sardella M., Mannarino O., Collini P., Casieri P., Cozzi D., Spreafico F., Radice P., Dominici C. Molecular evidence of the independent origin of multiple Wilms tumors in a case of WAGR syndrome. Ped Blood Cancer, 2008 Sep;51(3):344-8.  ** co-first author

22. Spreafico F., Bisogno G., Collini P., Jenkner A., Gandola L., Casazza G., Piva L., Luksch R., Perotti D., Fagioli F., Dallorso S. Treatment of High-Risk Relapsed Wilms Tumor with Dose-Intensive Chemotherapy, Marrow-Ablative Chemotherapy and Autologous Hematopoietic Stem Cell Support: Experience by the Italian Association of Pediatric Hematology and Oncology. Ped Blood Cancer, 2008 Jul;51(1):23-8.

23. Cerrato F., Sparago A., Verde G., De Crescenzo A., Citro V., Cubellis M.V., Rinaldi M.M., Boccuto L., Neri G., Magnani C., D’Angelo P., Collini P., Perotti D., Sebastio G., Maher E., Riccio A. Different Mechanisms Cause Imprinting defects at the IGF2/H19 locus in Beckwith-Wiedeman syndrome and Wilms’ tumour. Hum Mol Genet, 2008 May 15;17(10):1427-35.

24. Murrell A., Ito Y., Verde G., Huddleston J., Woodfine k., Cirillo Silengo M., Spreafico F., Perotti D., De Crescenzo A., Sparago A., Cerrato F., Riccio A. Different mechanisms cause loss of imprinting of the IGF2 gene in congenital growth disorders and cancer. PLoS ONE, 2008 Mar 26;3(3):e1849.

25. Perotti D., Gamba B., Sardella M., Spreafico F., Terenziani M., Collini P., Pession A., Nantron M., Fossati-Bellani F., and Radice P. on behalf of the AIEOP Wilms Tumor Study Group. Functional inactivation of the WTX gene is not a frequent event in Wilms tumors. Oncogene, 2008 Apr 7. 2008 Jul 31;27(33):4625-32

26. Terenziani M, Sardella M, Gamba B, Testi MA, Spreafico F, Ardissino G, Fedeli F, Fossati-Bellani F, Radice P, Perotti D. A novel WT1 mutation in a 46,XY boy with congenital bilateral cryptorchidism, nystagmus and Wilms tumor. Pediatr Nephrol, 2009, Jul 24(7):1413-7

27. Carella M, Spreafico F, Palumbo O, Storlazzi CT, Tabano  S, Miozzo M, Miglionico L, Calvano S, Sindici G, Gamba B, Impera L, Collini P, Zelante L, Radice P, Perotti  D. Constitutional Ring Chromosome 11 Mosaicism in a Wilms Tumor Patient: Cytogenetic, Molecular and Clinico-pathological studies. Am J Med Genet. July 2010, 152A (7): 1756-1763.

28. Perotti D, Radice P. Is WTX a suitable target for cancer therapy? 2011 Apr;56(4):682. doi: 10.1002/pbc.22947. Epub 2010 Dec 22

29. Spreafico F, Notarangelo LD, Schumacher RF, Savoldi G, Gamba B, Terenziani M, Collini P, Fasoli S, Giordano L, Luisa B, Porta F, Massimino M, Radice P, Perotti D. Clinical and molecular description of a Wilms tumor in a patient with tuberous sclerosis complex. Am J Med Genet A. 2011 Jun;155A(6):1419-24.

30. Venturini L, Daidone MG, Motta R, Collini P, Spreafico F, Terenziani M, Piva L, Radice P, Perotti D, Zaffaroni N. Telomere maintenance in Wilms tumors: First evidence for the presence of alternative lengthening of telomeres mechanism. Genes Chromosomes Cancer. 2011 Oct;50(10):823-9. doi: 10.1002/gcc.20903. Epub 2011 Jul 18

31. Perotti D, Spreafico F, Torri F, Gamba B, D'Adamo P, Pizzamiglio S, Terenziani M, Catania S, Collini P, Nantron M, Pession A, Bianchi M, Indolfi P, D'Angelo P, Fossati-Bellani F, Verderio P, Macciardi F, Radice P; Associazione Italiana Ematologia Oncologia Pediatrica Wilms Tumor Working Group. Genomic profiling by whole-genome single nucleotide polymorphism arrays in Wilms tumor and association with relapse. Genes Chromosomes Cancer. 2012 Jul;51(7):644-53.

32. Zicari AM, Tarani L, Perotti D, Papetti L, Nicita F, Liberati N, Spalice A, Salvatori G, Guaraldi F, Duse M. WTX R353X mutation in a family with osteopathia striata and cranial sclerosis (OS-CS): case report and literature review of the disease clinical, genetic and radiological features. Ital J Pediatr. 2012 Jun 20;38:27

33. Spreafico F, Gamba B, Mariani L, Collini P, D’Angelo P, Pession A, Di Cataldo A, Indolfi P, Nantron M, Terenziani M, Morosi C, Radice P, Perotti D. On behalf of the AIEOP Wilms Tumor Working Group. LOH analysis at  different  chromosome regions in Wilms tumor confirms 1p allelic loss as a marker of worse prognosis: a study from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP). J Urol. 2013 Jan;189(1):260-6.

34. Ciceri S, Cattaneo E, Fossati C, Radice P, Selicorni A, Perotti D. First evidence of vertical paternal transmission of osteopatia striata with cranial sclerosis. Am J Med Genet A. 2013 May;161A(5):1173-6.

35. Melchionda F, Spreafico F, Ciceri S, Lima M, Collini P, Pession A, Massimino M, Radice P, Perotti D. A novel WT1 mutation in familial wilms tumor. Pediatr Blood Cancer. 2013 Aug; 60(8):1388-9.

36. Calvello M, Tabano S, Colapietro P, Maitz S, Pansa A, Augello C, Lalatta F, Gentilin B, Spreafico F, Calzari L, Perotti D, Larizza L, Russo S, Selicorni A, Sirchia SM, Miozzo M. Quantitative DNA methylation analysis improves epigenotype-phenotype correlations in Beckwith-Wiedemann syndrome. Epigenetics. 2013 Aug 5;8(10).