Betel Quid Addiction: Blessing or curse, A study of North East Population of India
Introduction: Oral cancer is most common cancer in males and third most common in females, one of the main causative agent being use of chewing betel quid (BQ). Areca nut (Areca catechu), a major component of BQ, contains certain alkaloids that give rise to nitrosamines. CYP2A6 genetic polymorphism were studied among the Eastern and North eastern indian population .
Methods : In this present study subjects were screened from Department of E.N.T. & Oral and Maxillofacial surgery of RKMSP hospital, Kolkata and different areas of Eastern and North Eastern states of India. Polymorphism of CYP2A6 gene was studied from EDTA blood .
Results: Some of the cases had more than one addiction. It has been found that most of the subjects had betel quid chewing habit. Early metabolizer are susceptible to oral cancer where as in case of poor metabolizers chances are less.Conclusion: Betel quid has an immense role in changing the oral pathology and developing oral cancer.
Oral Cancer: Beware North East India. 2011.
Raghavan B, Barua HK. Areca nut: India’s Popular masticatory – History, Chemistry and Utilization . Econ Botany.1958, 12: 315-345
Marshal M. An overview of drugs in Ocenia. In: Lindstrom L, editor. Drugs in Western Pacific Socities: relations of substance . Lanham, Md: University Press of America.1987:13-50
IARC Betel Quid and Areca – Nut Chewing and some Areca-Nut-Derived Nitrosamine, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, IARC, Fairbanks, Alaska, USA. 2004, 85
Raunio H, Pasanen M, Maenpaa J, Hakkola J and Pelkonen O. Expression of extra hepatic cytochrome P450 in humans; in Advances in Drug metabolism in Man. eds G M Pacifici and G N Fracchia (Luxembourg European Commision). 1995:233-238
Fernandez-Salguero P, Gonzalez FJ. The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis. Pharmacogenetics. 1995; 5: S123-S128
Hoffman SMG, Fernandez-Salguero P, Gonzalez F J, Mohrenweiser HW. Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19. Journal of Molecular Evolution. 1995, 41(6):894-900
Tricker AR. Nicotine metabolism, human drug metabolism polymorphisms, and smoking behaviour. Toxicology. 2003, 183(1-3):151-173
Ingelman-Sundberg M. The Gerhard ZbindenMemorial Lecture. Genetic polymorphism of drug metabolizing enzymes. Implications for toxicity of drugs and other xenobiotics. Archives of Toxicology. Supplement.1997, 19:3-13
Namakura K, Yokoi T, Inoue K, Shimada N, Ohashi N, Kume T, and Kamataki T. CYP2D6 is the principal cytochrome P450 responsible for the metabolism of the histamine H1 antagonist promethazine in human liver microsomes. Pharmacogenetics. 1996, 6:449-457
Gonzalez FZ. The CYP2D subfamily. In C Ioannides, (ed.), Cytochrome P450, metabolic and toxicological aspects. CRC Press, New York.1996:183-211
- There are currently no refbacks.