Isolated Parotid Metastasis from Small Cell Lung Cancer
Worldwide, lung cancer accounts for the most cancer mortality in both men and women with 1.6 million deaths in 2012. Small cell lung cancer usually present as a disseminated disease in over 70% of the patients. Common site of metastasis include liver, adrenal, bone and brain. However, metastasis to parotid gland is uncommon described only in case reports. A 75-year old male presented with a mass on right parotid gland, biopsy confirmed metastatic small cell carcinoma. CT chest showed 5.5cm right hilar mass and mediastinal adenopathy T2bN2M1b, stage IV disease. He underwent chemotherapy Carboplatin and Etoposide. Small cell lung cancer diagnosed from isolated metastasis to parotid gland is rare. Physicians should be aware of pulmonary source when presented with a parotid tumor. Overall, the finding has a poor prognosis but main modality of treatment is palliative with systemic chemotherapy and possible irradiation for symptomatic control.
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin 2016; 66:7.
Bumpous J. Metastatic cutaneous squamous cell carcinoma to the parotid and cervical lymph nodes: treatment and outcomes. Curr Opin Otolaryngol Head Neck Surg. 2009;17:122–125.
Nuyens M, Schu¨pbach J, Stauffer E. Metastatic disease to the parotid gland. Otolaryngol Head Neck Surg 2006; 135:844-848.
Perlikos F, Harrington KJ, Syrigos KN. Key molecular mechanisms in lung cancer invasion and metastasis: a comprehensive review. Crit Rev Oncol Hematol. 2013 Jul;87(1):1-11.
Alvarado-Luna G, Morales-Espinosa D. Treatment for small cell lung cancer, where are we now?-a review. Transl Lung Cancer Res. 2016 Feb;5(1):26-38.
Ulubas B, Ozcan C, Polat A. Small cell lung cancer diagnosed with metastasis in parotid gland. J Craniofac Surg. 2010; 21:781–783.
Raut V, Sinnathuray AR, Primrose WJ. Aggressive treatment of metastasis to the parotid. Ulster Med J. 2004; 73:85–88.
Shi S, Fang QG, Liu FY, Sun CF. Parotid gland metastasis of lung cancer: a case report. World J Surg Oncol. 2014 Apr 24; 12:119.
Kalemkerian GP, Schneider BJ. Advances in Small Cell Lung Cancer. HematolOncol Clin North Am. 2017 Feb;31(1):143-156.
- There are currently no refbacks.