Cover Image

A Rare Case of Metastatic Urachal Carcinoma

Rania Chacha, Daniela Petran, Jerome Dauba, Said Afqir

Abstract


Urachal carcinoma is a rare tumor, it represents about 0.5-1% of all bladder malignancies.  In the majority of cases it is an adenocarcinoma. For the treatment it is recommended for resectable tumors, a partial cystectomy with resection of the urachal ligament, the bladder dome and umbilicus. There is no standard neoadjuvant or adjuvant treatment, and the combinations of 5-fluoruracil with cisplatin are active in metastatic stage. A higher risk of relapse after surgery has been observed in some situations:  positive margins, lymph node involvement, involvement of the peritoneal surface, or in the case of the umbilicus was not resected en-bloc.


Keywords


urachus; adenocarcinoma; immunotherapy

References


Severson CR. Enhancing nurse practitioner understanding of urachal anomalies. J Am Acad Nurse Pract. 2011, 23(1):2-7

Koster IM, Cleyndert P, Giard RW. Best cases from the AFIP: urachal carcinoma. Radio Graphics. 2009, 29(3):939-942

Dhillon J, Liang Y, Kamat AM, et al. Urachal carcinoma: a pathologic and clinical study of 46 cases. Hum Pathol. 2015, 46(12):1808-1814

Begg RC. The Urachus: its anatomy, histology and development. Journal of Anatomy. 1930, 64(Part 2):170-183

Hue L, Jacquin M. Cancer colloide de la lombille et de paroi abdominale anterieure ayant envahi la vessie. Union Med de la Siene-Inf Rouen. 1863, 6:418-420

Cullen TB. Embryology, Anatomy, and Diseases of the Umbilicus Together with Diseases of the Urachus. Philadelphia, PA, USA: W. B. SAUNDERS COMPANY

Gopalan A, Sharp DS, Fine SW, et al. Urachal carcinoma: a clinicopathologic analysis of 24 cases with outcome correlation. The American Journal of Surgical Pathology. 2009, 33(5):659-668

Johnson DE, Hodge GB, Abdul-Karim FW, Ayala AG. Urachal carcinoma. Urology. 1985, 26(3):218-221

Pinthus JH., Haddad R, Trachtenberg J, et al. Population based survival data on urachal tumors. The Journal of Urology. 2006, 175(6):2042-2047

Sheldon CA, Clayman RV, Gonzalez R, Williams RD, Fraley EE. Malignant urachal lesions. The Journal of Urology. 1984, 131(1):1-8

Siefker-Radtke AO, Gee J, Shen Y, et al. Multimodality management of urachal carcinoma: the M. D. Anderson Cancer Center experience. J Urol. 2003, 169:1295-1298

Guarnaccia S, Pais V, Grous J, et al. Adenocarcinoma of the urachus associated with elevated levels of CA 125. J Urol. 1991, 145:140-141

Ashley RA, Inman BA, Sebo TJ, et al. Urachal carcinoma: clinicopathologic features and long-term outcomes of an aggressive malignancy. Cancer. 2006, 107:712-720


Full Text: PDF

Refbacks

  • There are currently no refbacks.


AJCC-REP (ISSN 2572-5742)Copyright © 2012-2019. All rights reserved. Published by Ivy Union Publishing, 3204 Valley Rush Dr, Apex, North Carolina 27502, United States