Cover Image

Vagal Nerve Schwannoma Clinically Mimicking Gastrointestinal Stromal Tumor: Report of a Case

Safak Ozturk, Kerem Karaman, Emel Ebru Pala, Umit Bayol, Mutlu Unver, Burcin Kibar Ozturk, Cengiz Aydın, Cezmi Karaca

Abstract


Introduction: Mesenchymal tumors of the gastrointestinal (GI) tract are mainly comprised of a spectrum of spindle cell tumors which include gastrointestinal stromal tumors (GISTs), leiomyomas or leiomyosarcomas, and schwannomas. As all of these tumors of the GI are located in the submucosal layer of the bowell wall, differential diagnosis is very difficult. Histopathological evaluation using immunohistochemical staining is required for the definitive diagnosis.

Presentation of case: A 20-year-old female patient was presented with an upper abdominal pain and dyspepsia since 2 months duration.This case  is initially thought as GIST but finally diagnosed as vagal nerve schwannoma by histopathological evaluation after resection of the mass.

Conclusion: Schwannomas should be considered in the differential diagnosis of other mesenchimal tumors, such as gastrointestinal stromal tumors and leiomyomas or leiomyosarcomas, indeed it can grow in any part of the peripheral nerves along the gastrointestinal tract. Histopathological evaluation including immunohistochemical staining is required for the definitive diagnosis.


Keywords


Schwannoma; Neurilemoma; Mesenchymal tumor; Gastrointestinal stromal tumor

Full Text:

PDF

References


Kurtkaya-Yapicier O, Scheithauer B, Woodruff JM. The pathobiologic spectrum of Schwannomas. Histol Histopathol 2003; 18: 925-34.

Prévot S, Bienvenu L, Vaillant JC, de Saint-Maur PP. Benign schwannoma of the digestive tract: a clinicopathologic and immunohistochemical study of five cases, including a case of esophageal tumor. Am J Surg Pathol 1999; 23: 431-6.

M. R. Sreevatsa, Ranganath Vitlapur Srinivasarao. Three Cases of Vagal Nevre Schwannoma and Review of Literature. Indian J Otolaryngol Head Neck Surg 2011; 63: 310-2

M. H. Raber, C. M. P. Z. des Plantes, R. Vink, R. Vink, J. M. Klaase. Gastric schwannoma presenting as an incidentaloma on CT-scan and MRI. Gastroenterology Research 2010; 3: 276–80.

Benz MR, Czernin J, Dry SM, Tap WD, Allen-Auerbach MS, Elashoff D, et al. Quantitative F18-fluorodeoxyglucose positron emission tomography accurately characterizes peripheral nerve sheath tumors as malignant or benign. Cancer 2010; 116: 451-8.

Voltaggio L, Murray R, Lasota J, Miettinen M. Gastric schwannoma: a clinicopathologic study of 51 cases and critical review of the literature. Hum Pathol 2012; 43: 650-9.

Fülöp E, Marcu S, Borda A, Moldovan C, Fülöp EF, Loghin A, et al. Histopathological and immunohistochemical features of gastrointestinal stromal tumors. Rom J Morphol Embryol 2011;52:555-62.

Boşoteanu M, Boşoteanu C, Deacu M, Aşchie M. Differential diagnosis of a gastric stromal tumor: case report and literature review. Rom J Morphol Embryol 2011; 52: 1361-8.

William Yoon, Kari Paulson, Paul Mazzara, Sweety Nagori, Mohammed Barawi, Richard Berri. Gastric Schwannoma: A Rare but Important Differential Diagnosis of a Gastric Submucosal Mass. Case Rep Surg 2012; 2012:280982.

Theodosopoulos T, Stafyla VK, Tsiantoula P, Yiallourou A, Marinis A, Kondi-Pafitis A, et al. Special problems encountering surgical management of large retroperitoneal schwannomas. World J Surg Oncol 2008; 6:107.

Langner E, Del Negro A, Akashi HK, Araújo PP, Tincani AJ, Martins AS. Schwannomas in the head and neck: retrospective analysis of 21 patients and review of the literature. Sao Paulo Med J 2007 Jul 5;125(4):220-2.

Koichi Oishi, Toshiyuki Itamoto, Sho Okimoto, Takashi Nishisaka. Multiple Retroperitoneal Schwannomas Mimicking Adrenal Tumors. Case Rep Oncol 2012; 5: 222-228.

David J. Hobbs, Jennifer McLellan, Marc G. Schlatter. Schwannoma of the diaphragm- a pediatric case report and review of the literature. J Ped Surg 2012; 47: E5-E7.


Refbacks

  • There are currently no refbacks.


AJCC-REP (ISSN 2572-5742)Copyright © 2012-2020. All rights reserved. Published by Ivy Union Publishing, 3204 Valley Rush Dr, Apex, North Carolina 27502, United States