Cover Image

Triple Synchronous Tumors in a Patient: Gastric Adenocarcinoma, Omental Gastrointestinal Stromal Tumor and Renal Angiomyolipoma

SEVİNÇ ŞAHİN, Selda Seçkin, Ergin Arslan, Kasım Çağlayan, Kürşad Zengin, Serhat Tanık

Abstract


Introduction: The presence of synchronous distinct tumors is uncommon in the literature, and the etiology of it is still unknown.

Presentation of Case: Herein, we report a 42 year-old-woman with synchronous triple tumors of gastric adenocarcinoma, renal angiomyolipoma (AML), and omental gastrointestinal stromal tumor (GIST). She underwent total gastrectomy after the diagnosis of adenocarcinoma by endoscopic biopsy. During macroscopic examination of gastrectomy specimen, an ulcerated tumor about 4.5 cm in diameter was observed in the fundus. Histopathologically, it was diagnosed as adenocarcinoma harboring some signet-ring features. While dissecting lymph nodes of the omentum of the lesser curvature, a nodular mass about 4.2 cm in diameter seemed to be a lymph node was detected macroscopically. However, it was diagnosed as GIST by histopathological and immunohistochemical features. Also, partial nephrectomy was performed during the same session due to a mass detected radiologically in the left kidney about 2.2 cm in diameter. It was indicated to be metastatic gastric adenocarcinoma clinically but AML was determined by histopathological and immunohistochemical findings.

Conclusion: To the best of our knowledge, our patient is the first case in the literature that has synchronous tumors of gastric adenocarcinoma, omental GIST and renal AML.


Keywords


Adenocarcinoma; angiomyolipoma; gastric; GIST; triple; synchronous

Full Text:

PDF

References


Firat Ö, Çalışkan C, Karaca C, Sezak M, Özütemiz Ö, Ersin S, Güler A. Coexistence of gastric cancer and gastrointestinal stromal tumor: report of two cases. Turk J Gastroenterol. 2010, 21: 302-4

Zhou Y, Wu XD, Shi Q, Jia J. Coexistence of gastrointestinal stromal tumor, esophageal and gastric cardia carcinomas. World J Gastroenterol. 2013, 19:2005-8

Idema DL, Daryanani D, Sterk LM, Klaase JM.Collision tumor of the stomach: a case of an adenocarcinoma and a gastrointestinal stromal tumor. Case Rep Gastroenterol. 2008, 2: 456-60

Sema B, Özden C, Şerife A, Şirin B, Mahmut B, Nilgün K, Nermin K, Metin Ç. Synchronous primary adenocarcinoma and gastrointestinal stromal tumor in the stomach: A report of two cases. Turk J Gastroenterol. 2004, 15: 187-191

Vogel Y, Müller C, Uhl W, Tannapfel A. Coexistence of multifocal gastric adenocarcinoma with signet-ring cell morphology and a gastrointestinal stromal tumour in a stomach with hp-associated gastritis. Z Gastroenterol. 2011, 49: 201-6

Salemis NS, Gourgiotis S, Tsiambas E, Karameris A, Tsohataris E. Synchronous occurrence of advanced adenocarcinoma with a stromal tumor in the stomach: a case report. J Gastrointestin Liver Dis. 2008, 17: 213

Liu YJ, Yang Z, Hao LS, Xia L, Jia QB, Wu XT. Synchronous incidental gastrointestinal stromal and epithelial malignant tumors. World J Gastroenterol. 2009, 15: 2027-31

Bosman FT, Carneiro F, Hruban RH, Theise ND (eds): WHO Classification of Tumours of the Digestive System. Lyon: IARC Press; 2010

Fagkrezos D, Touloumis Z, Giannila M, Penlidis C, Papaparaskeva K, Triantopoulou C. Extra-gastrointestinal stromal tumor of the omentum: a rare case report and review of the literature. Rare Tumors. 2012, 4: 44

Sakurai S, Hishima T, Takazawa Y, Sano T, Nakajima T, Saito K, Morinaga S, Fukayama M. Gastrointestinal stromal tumors and KIT positive mesenchymal cells in the omentum. Pathol Int. 2001, 51: 524-31

Abraham SC. Distinguishing gastrointestinal stromal tumors from their mimics: an update. Adv Anat Pathol. 2007, 14: 178-88

Kang GH, Srivastava A, Kim YE, Park HJ, Park CK, Sohn TS, Kim S, Kang DY, Kim KM. DOG1 and PKC-θ are useful in the diagnosis of KIT-negative gastrointestinal stromal tumors. Mod Pathol. 2011, 24: 866-75

Miettinen M, Lasota J. Gastrointestinal stromal tumors. Review on morphology, molecular pathology, prognosis and differential diagnosis. Arch Pathol Lab Med. 2006, 130: 1466–78

Zhou M, Netto GJ, Epstein JI. Uropathology: High-Yield pathology. Philadelphia: Elsevier/Saunders; 2012

Folpe AL, Inwards CY. Bone and soft tissue pathology. Philadelphia: Saunders/Elsevier; 2010

Gonçalves R, Linhares E, Albagli R, Valadão M, Vilhena B, Romano S, Ferreira CG. Occurrence of other tumors in patients with GIST. Surg Oncol. 2010, 19: 140-3

Ferreira SS, Werutsky G, Toneto MG, Alves JM, Pianta CD, Breunig RC, Brondani da Rocha A, Grivicich I, Garicochea B. Synchronous gastrointestinal stromal tumors (GIST) and other primary cancers: case series of a single institution experience. Int J Surg. 2010, 8: 314-7

Radopoulos D, Tahmatzopoulos A, Kalinderis N, Dimitriadis G. Bilateral synchronous occurrence of three different histological types of renal tumor: a case report. J Med Case Rep. 2009, 3: 6798

Val-Bernal JF, Hernandez-Nieto E, Garijo MF. Association of cystic nephroma with angiomyolipoma in the same kidney. Pathol Res Pract. 2000, 196: 583-8

Dong A, Wang Y, Zuo C. Synchronous pure epithelioid angiomyolipoma of the kidney and retroperitoneal schwannoma in the same patient on 18F-FDG PET/CT imaging. Clin Nucl Med. 2013, 38: 98-100

Mogi Y, Takimoto R, Kura T, Tamakawa M, Sakamaki S, Niitsu Y. Retroperitoneal extrarenal angiomyolipoma with early gastric carcinoma. J Gastroenterol. 1998, 33: 86-90

Carlos Eduardo Paiva, Francisco Alves Moraes Neto, Abbas Agaimy, Maria Aparecida Custódio Domingues, Silvia Regina Rogatto. Perivascular epithelioid cell tumor of the liver coexisting with a gastrointestinal stromal tumor. World J Gastroenterol. 2008, 14: 800-802


Refbacks

  • There are currently no refbacks.


AJCC-REP (ISSN 2572-5742)Copyright © 2012-2020. All rights reserved. Published by Ivy Union Publishing, 3204 Valley Rush Dr, Apex, North Carolina 27502, United States