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Metastatic Clear Cell Hidradenocarcinoma: Response to Chemotherapy and Long Disease Control

Mouna Ayadi, Feryel Letaief ksontini, Khadija Meddeb, Amina Mokrani, Yosra Yahyaoui, Nesrine Chrait, Henda Rais H, Khadija Bellil, Amel Mezlini

Abstract


Introduction: Hidradenocarcinoma is a rare aggressive tumor arising from sweat glands that may occur from preexisting hidradenoma or most frequently appears de novo. It is often located in the head and neck. It is also characterized by a high potential of local recurrence, metastasis and poor outcome. This tumor is often radiotherapy and chemotherapy resistant.

Presentation of case: We report a case of a 77-year-old man with a metastatic hidradenocarcinoma to the bone and lymph nodes who was operated 7 years ago for an hidradenoma of the right foot. He was treated with capecitabine-based chemotherapy with good tolerance and obtention of partial response during 10 months. After that, his disease progressed and he died 1 year after diagnosis.

Conclusion: Hidradenocarcinoma is a cancer with a poor prognosis . Because of its low prevalence and high rate of recurrence, its treatment is still controversial. Our good result demonstrates that adjunction of chemotherapy in metastatic forms is effective for a better control and long overall survival.


Keywords


Metastatic Hidradenocarcinoma; chemotherapy; capecitabine; disease control

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References


Gauerke S, Driscoll JJ. Hidradenocarcinomas: A Brief Review and Future Directions. Arch Pathol Lab Med. 2010, 134:781-785

Yavel R, Hinshaw M, Rao V Hartig GK, Harari PM, Stewart D, Snow SN. Hidradenoma and hidradenocarcinoma of the scalp. Managed using Mohs micrographic surgery and a multidisciplinary approach: case reports and review of the literature.Dermatol Surg.2009, 35:273-281

MehreganAH , Hashimoto K, Rahbari H. Eccrine adenocarcinoma. A clinicopathologic study of 35 cases. Arch Dermatol.1983, 119(2):104-114.

Santa Cruz DJ. Sweat gland carcinomas a comprehensive review. SeminDiagn Pathol.1987, 4(1):38-74

Kaesby LE, Hadley GG. Clear cell adenocarinoma: report of three cases with widespread metastases. Cancer.1954, 7(5):934-952

Chintamani, Sharma R, Badran R, Badran R, Singhal V, Saxena S, Bansal A.Metastatic sweat gland adenocarcinoma: A clinico-pathological dilemma. World J SurgOncol.2003, 1(1):13

Shu k, Xiao Q, Büchele F, Zhang S, Jiang W, Lei T. Diagnosis and treatment of clear cell hidradenocarcinoma of the scalp.J Huazhong Univ Sci Technolog Med Sci.2012, 32(6):931-936

Wildermore JK, Lee JB, Humphreys TR.Mohs surgery for malignant eccrine neoplasms. Dermatol Surg. 2004, 30(12 Pt 2):1574-1579

Song SS, Wu Lee W, Hamman MS, Brian Jiang SI.Mohs micrographic Surgery for eccrine porocarcinoma: An update and review of the literature. Dermatol Surg. 2015, 41(3):301-306

Delgado R, Kraus D, Coit DG, Busam KJ. Sentinel lymph node analysis in patients with sweat gland carcinoma. Cancer.2003, 97(9):2279-2284

Lalya I, Hadadi K, Tazi el M, Lalya I, Bazine A, Andaloussy K, Elmarjany M, Sifat H, Hassouni K, Kebdani T, Mansouri H, Benjaafar N, Elgueddari BK. Radiotherapy on hidradenocarcinoma. N Am J Med Sci. 2011, 3(1):43-45

Harari PM,Shimm DS, Bangert JL, Cassady JR. The role of radiotherapy in the treatment of malignant sweat gland neoplasms. Cancer. 1990, 65(8):1737-1740

Jouary T, Kaiafa A, Lipinski P, Vergier B, Lepreux S, Delaunay M, Taïeb A. Metastatic hidradenocarcinomas: efficacy of capecitabine. Arch Dermatol.2006, 142(10):1366-1367

Trabelsi A, Olfa G, Faten H, Makrem H, Slim BA, Moncef M. Metastatic hidradenocarcinoma: surgery and chemotherapy.North Am J Med Sci.2009, 1(7):372-374

Wan X, Wang HY, Zheng JN, Sui JC. Primary cutaneous sweat gland carcinoma.J Cancer Res Ther.2014, 10(2):390-92

Kasi S, Benedetto P, Otrakji CL, Charyulu KK.. Reponse of eccrine adenocarcinoma to tamoxifen. Cancer.1989, 64(2):366-370

Schroder U, Dries V, Klussmann JP, Wittekindt C, Eckel HE. Successful adjuvant tamoxifen therapy for oestrogen receptor-positive metastasizing sweat gland adenocarcinoma. Ann Otol Rhinol Laryngol.2004, 113 (3 Pt 1):242-244


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