Cover Image

T Cell Lymphoma: A Rough Road to Diagnosis

priya Tiwari, Ajay Gogia, Devjit Nath

Abstract


Introduction: Lymphoproliferative disorders are well known for their variable presentation. Peripheral T cell lymphoma not otherwise specified (PTCL-NOS) is one subtype which is especially notorious. It has a variable age of onset, predominantly a nodal presentation and immunohistochemistry (IHC) depicting mature T cells.

Presentation of case: We share our experience of a 33 year old patient who presented with mediastinal mass with pericardial effusion. However the histopathology revealed PTCL-NOS

Conclusion: This case in one of the manifestations of heterogeneity encompassing T cell neoplasms where discordance in clinical and pathological behaviour caused not only diagnostic confusion but also complicated treatment decisions.

 


Keywords


lymphoma; Mediastinum; T cell

Full Text:

PDF

References


Van Besien, K, Kelta, M, Bahaguna, P. Primary mediastinal B-cell lymphoma: A review of pathology and management. J Clin Oncol. 2001, 19:1855

Tataroglu C, Sarioglu S, Kargi A, Ozkal S, Aydin O. Fibrosis in Hodgkin and non-Hodgkin lymphomas. Pathol Res Pract. 2007, 203(10):725-30

Nakamura S, Takagi N, Kojima M, Motoori T, Kitoh K, Osada H, Suzuki H, Ogura M, Kurita S, Oyama A. Clinicopathologic study of large cell anaplastic lymphoma (Ki-1-positive large cell lymphoma) among the Japanese. Cancer. 1991, 68(1):118-29

Rizzo FA, Vilar EG, Pantaleão L, Fonseca EC, Magrin PF, Henrique-Xavier M, Rochael MC. Mycosis fungoides in children and adolescents: a report of six cases with predominantly hypopigmentation. Dermatol Online J. 2012, 18(3):5

Shapiro PE, Pinto FJ. The histologic spectrum of mycosis fungoides/Sezary syndrome (cutaneous T-cell lymphoma). A review of 222 biopsies, including newly described patterns and the earliest pathologic changes. Am J Surg Pathol. 1994, 18(7):645-667

Suzumiya J, Ohshima K, Kikuchi M, Takeshita M, Akamatsu M, Tashiro K. Terminal deoxynucleotidyl transferase staining of malignant lymphomas in paraffin sections: a useful method for the diagnosis of lymphoblastic lymphoma. J Pathol. 1997, 182:86-91

Soslow RA, Bhargava V, Warmke RA. MIC-2, TdT, bcl-2, CD34 expression in paraffin-embedded high-grade lymphoma/acute lymphoblastic leukemia distinguish between distinct clinicopathologic entities. Hum Pathol. 1997, 28:1158-1165

Terada T. TDT (-), KIT (+), CD34 (+), CD99 (+) precursor T lymphoblastic leukemia/lymphoma. Int J Clin Exp Pathol. 2012, 5(2): 167-170.

Weisenburger DD, Savage KJ, Harris NL, Gascoyne RD, Jaffe ES, MacLennan KA, Rüdiger T, Pileri S, Nakamura S, Nathwani B, Campo E, Berger F, Coiffier B, Kim WS, Holte H, Federico M, Au WY, Tobinai K, Armitage JO, Vose JM. Peripheral T-cell lymphoma, not otherwise specified: a report of 340 cases from the International Peripheral T-cell Lymphoma Project. Blood. 2011, 117:3402

Chihara D, Oki Y, Ine S et al. Analysis of prognostic factors in peripheral T-cell lymphoma: prognostic value of serum albumin and mediastinal lymphadenopathy. Leuk Lymphoma. 2009, 50(12):1999-2004


Refbacks

  • There are currently no refbacks.


AJCC-REP (ISSN 2572-5742)Copyright © 2012-2020. All rights reserved. Published by Ivy Union Publishing, 3204 Valley Rush Dr, Apex, North Carolina 27502, United States