Cover Image

Primary Breast Sarcoma: A Case Report

Richard Downs Wagner, Rakhshanda Rahman

Abstract


Introduction: Breast sarcomas are very rare, accounting for less than 1% of all breast malignancies and less than 5% of all soft tissue sarcomas [1,2]. They can develop as primary malignancies or secondary to radiation therapy or after treatment of another malignancy [3,4]. Primary breast sarcomas are particularly rare, accounting for only 44.8 new cases per 10 million women [5]. Because breast sarcomas are so rare, clinical research is difficult and there is little data to guide management. Most published data on breast sarcomas is limited to small retrospective case reviews and case reports.

Case presentation: A 65 year-old woman presented with a three week history of swelling and bleeding of her left breast. On initial exam, there was an ulcerated, exophytic multinodular mass of the inferior, medial aspect of the right breast measuring approximately 18 cm. Ultrasound guided biopsy was performed which revealed the mass was a high grade pleomorphic breast sarcoma. The patient underwent a right mastectomy. Three months later, the patient re-presented with a bleeding lesion on her scalp. Fine needle aspiration was performed, which revealed a high grade, poorly differentiated malignancy.

Conclusion: This case represents a very rare form of breast sarcoma and could potentially contribute to the body of scientific evidence on breast sarcomas. A centralized registry might be able to compile this and other evidence for further analysis to better understand breast sarcomas and guide management.


Keywords


breast cancer; breast sarcoma

Full Text:

PDF

References


McGowan TS, Cummings BJ, O'Sullivan B, Catton CN, Miller N, Panzarella T. An analysis of 78 breast sarcoma patients without distant metastases at presentation. Int J Radiat Oncol Biol Phys. 2000, 46(2):383-390

Russell WO, Cohen J, Edmonson JH, Enzinger F, Hajdu SI, Heise H, Martin RG, Miller WT, Schmitz RL, Suit HD. Staging system for soft tissue sarcoma. Semin Oncol. 1981, 8(2):156-159

Huang J, Mackillop WJ. Increased risk of soft tissue sarcoma after radiotherapy in women with breast carcinoma. Cancer. 2001, 92(1):172-180

Blanchard DK, Reynolds C, Grant CS, Farley DR, Donohue JH. Radiation-induced breast sarcoma. Am J Surg. 2002, 184(4):356-358

May DS, Stroup NE. The incidence of sarcomas of the breast among women in the United States, 1973-1986. Plast Reconstr Surg. 1991, 87(1):193-194

Berg JW, Hutter RV. Breast cancer. Cancer. 1995, 75(1 Suppl):257-269

Zelek L, Llombart-Cussac A, Terrier P, Pivot X, Guinebretiere JM, Le Pechoux C, Tursz T, Rochard F, Spielmann M, Le Cesne A. Prognostic factors in primary breast sarcomas: a series of patients with long-term follow-up. J Clin Oncol. 2003, 21(13):2583-2588

Vorburger SA, Xing Y, Hunt KK, Lakin GE, Benjamin RS, Feig BW, Pisters PW, Ballo MT, Chen L, Trent J, Burgess M, Patel S, Pollock RE, Cormier JN. Angiosarcoma of the breast. Cancer. 2005, 104(12):2682-2688

Brady MS, Garfein CF, Petrek JA, Brennan MF. Post-treatment sarcoma in breast cancer patients. Ann Surg Oncol. 1994, 1(1):66-72

Karlsson P, Holmberg E, Johansson KA, Kindblom LG, Carstensen J, Wallgren A. Soft tissue sarcoma after treatment for breast cancer. Radiother Oncol. 1996, 38(1):25-31

Lagrange JL, Ramaioli A, Chateau MC, Marchal C, Resbeut M, Richaud P, Lagarde P, Rambert P, Tortechaux J, Seng SH, de la Fontan B, Reme-Saumon M, Bof J, Ghnassia JP, Coindre JM. Sarcoma after radiation therapy: retrospective multiinstitutional study of 80 histologically confirmed cases. Radiation Therapist and Pathologist Groups of the Fédération Nationale des Centres de Lutte Contre le Cancer. Radiology. 2000, 216(1):197-205

Woodward AH, Ivins JC, Soule EH. Lymphangiosarcoma arising in chronic lymphedematous extremities. Cancer. 1972, 30(2):562-572

Moore MP, Kinne DW. Breast sarcoma. Surg Clin North Am. 1996, 76(2):383-392

Pandey M, Mathew A, Abraham EK, Rajan B. Primary sarcoma of the breast. J Surg Oncol. 2004, 87(3):121-125


Refbacks

  • There are currently no refbacks.


AJCC-REP (ISSN 2572-5742)Copyright © 2012-2020. All rights reserved. Published by Ivy Union Publishing, 3204 Valley Rush Dr, Apex, North Carolina 27502, United States