Cover Image

Synchronous Adenocarcinoma and Neuroendocrine Tumors of the Stomach

Michelle Selma Mitchell, Lesley Walinchus-Foster, Lisa Thomas, Qi Shi, Maria Nagori, Waheed Khan, Wasique Mirza, Michael Cortes, Ossama Al Masalmeh, Hasan Zerti, Abdulla Mohamed

Abstract


Introduction: Synchronous tumors of the stomach have been reported in a limited number of case reports in the literature. Gastric neuroendocrine tumors are uncommon and account for 0.3% of gastric neoplasms. The coexistence of adenocarcinoma and carcinoid tumors in the stomach is exceedingly rare.  

Presentation of Case: We report a rare case of two primary, histologically distinct, synchronous cancers of the stomach in a 70-year-old male. The patient presented for evaluation of a pre-syncopal episode. Lab data confirmed a normocytic/normochromic anemia with a hemoglobin of 6.6 g/d, hematocrit of 20.3%, and MCV of 86.1fL. An EGD was completed which demonstrated a 30 mm polypoid ulcerative mass in the gastric antrum and a 12 mm polyp in the gastric body. Pathological assessment confirmed adenocarcinoma and neuroendocrine (carcinoid) malignancies respectively.

Conclusion: There have been limited case reports of patients with two separate, synchronous gastric malignancies. Additional reports of these cases would be necessary so appropriate screening and surveillance recommendations can be established, particularly if there is a coexistent history of autoimmune disease.

Keywords


Gastric adenocarcinoma; synchronous tumors; neuroendocrine; carcinoid; malignancy

Full Text:

PDF

References


Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA: A Cancer Journal for Clinicians. 2011, 61:69-90

Dicken BJ, Bigam DL, Cass C, Mackey JR, Joy AA, Hamilton SM. Gastric adenocarcinoma: Review and considerations for future directions. Annals of Surgery. 2005, 241:27-39

Godwin JD. Carcinoid tumors an analysis of 2837 cases. Cancer. 1975, 36:560-569

Morishita Y, Sugitani M, Sheikh A, Nemoto N, Fujii M, Takayama T. Collision tumor of the stomach: A rare case of an adenocarcinoma and carcinoid tumor. Archives of Pathology & Laboratory Medicine. 2005, 129:407-409

Kupková B, Rejchrt S, NoÏiãka J, Repák R, Kopáãová M, Filip S, Bure J. Synchronous gastric tumours (carcinoid and adenocarcinoma)-report of two cases. Please add the detailed information for this reference.

Kim EY, Park KC, Kwon JG. [A case of double primary cancer: Early gastric adenocarcinoma associated with adenocarcinoma and carcinoid]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi. 2003, 42:533-538

Olinici CD, Crişan D, Racu I. Synchronous gastric adenocarcinoma and carcinoid. Rom J Gastroenterol. 2004, 13:135-137

Sawalakhe NR, Nistala SU, Sasidharan M, Narendran RT, Amrapurkar AD, Joshi RM, Rathi PM. Synchronous gastric carcinoid and gastric adenocarcinoma with plummer-vinson syndrome: A case report and literature review. 2009

Vannella L, Lahner E, Osborn J, Annibale B. Systematic review: Gastric cancer incidence in pernicious anaemia. Alimentary pharmacology & therapeutics. 2013, 37:375-382

Lahner E, Centanni M, Agnello G, Gargano L, Vannella L, Iannoni C, Delle Fave G, Annibale B. Occurrence and risk factors for autoimmune thyroid disease in patients with atrophic body gastritis. The American Journal of Medicine. 121:136-141

Neufeld M, Maclaren N, Blizzard R. Autoimmune polyglandular syndromes. Pediatric annals. 1980, 9:154-162


Refbacks

  • There are currently no refbacks.


AJCC-REP (ISSN 2572-5742)Copyright © 2012-2020. All rights reserved. Published by Ivy Union Publishing, 3204 Valley Rush Dr, Apex, North Carolina 27502, United States