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Organ Specific Cancer Incidence in an Industrial Sub-district: A Population-based Study with 12 Years Follow-up

Yakir Rottenberg, Aviad Zick, Micha Barchana, Tamar Peretz


Background: Although emissions from petrochemical industries have been recognized as a cause of an increased in cancer deaths, its contribution to specific organ cancer incidence has not been investigated in a cohort study with an adequate sample size.

Objectives: To assess the association between organ specific cancer incidence and living in industrial subdistrict compared to other areas in Israel after controlling for socio- demographic variables.

Methods: Retrospective cohort study using baseline measurements from the Central Bureau of Statistics 1995 census living in the Haifa subdistrict, which houses major industrial facilities in Israel, compared to the rest of Israel. The census database was linked with the Israel Cancer Registry for cancer data. Smoking prevalence data was obtained from the Central Bureau of Statistics 1996/7 and 1999/2000 health surveys.

Results: A total of 175704 persons were included with a total of 8034 cancer cases. The mean age was 31 years (range: 0-101 years). In the analysis including all the target population the hazard ratio to develop cancer comparing Haifa subdistrict to non- Haifa was 1.16 (95% CI: 1.11-1.21, p<0.001) after adjusted for age, gender, Jews vs. non-Jews and continent of birth. Compared to the incidence in the rest of Israel, the Haifa subdistrict population had an elevated hazard ratio of lung, head and neck, colorectal, gastric and esophagus, bladder and cervical carcinoma. In discrepancy with this observation, people in the Haifa sub-district do not smoke more than in the rest of Israel.

Conclusions: We report an increased risk of developing cancer in a heavily industrialized sub-district, mainly among sites which are very similar to cancer sites caused by smoking.


Shirav-Schwartz, M. Geochemistry of sediments and soils in the Western Galillee-Carmel. Geological Survey of Israel: report no. GSI/31/2009. Jerusalem, Israel; Geological Survey of Israel. 2009 [in Hebrew]

Garty J, Weissman L, Cohen Y, Karnieli A, Orlovsky L. Transplanted lichens in and around the Mount Carmel National Park and the Haifa Bay industrial region in Israel: physiological and chemical responses. Environ Res. 2001, 85:159-176

Barchana, M. Geographical mapping of malignant diseases in Israel (2001–2005), Israel National Cancer Registry. Jerusalem, Israel; Ministry of Health; 2007 [in Hebrew]

Eitan O, Yuval, Barchana M, Dubnov J, Linn S, Carmel Y, Broday DM. Spatial analysis of air pollution and cancer incidence rates in Haifa Bay, Israel. Sci Total Environ. 2010, 408:4429-4439

Jemal A, Siegel R, Ward E, Hao Y, Xu, J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin. 2009, 59:225-249

Barchana M, Alon R, Lifshitz I. Incidence Trends of malignant diseases in Israel 1990-2006. Jerusalem, Israel; Ministry of Health; 2008 [in Hebrew]

Keinan-Boker L, Vin-Raviv N, Liphshitz I, Linn S, Barchana M. Cancer incidence in Israeli Jewish survivors of World War II. J Natl Cancer Inst. 2009, 101:1489-1500

Jemal A, Thun MJ, Ries LA, Howe HL, Weir HK, Center MM, Ward E, Wu XC, Eheman. Annual report to the nation on the status of cancer, 1975-2005, featuring trends in lung cancer, tobacco use, and tobacco control. J Natl Cancer Inst. 2008, 100:1672-1694

Vineis P, Hoek G, Krzyzanowski M, Vigna-Taglianti F, Veglia F, Airoldi L, Overvad K, Raaschou-Nielsen O, Clavel-Chapelon F, Linseisen J, Boeing H, Trichopoulou A, Palli D, Krogh V, Tumino R, Panico S, Bueno-De-Mesquita HB, Peeters PH, Lund E E, Agudo A, Martinez C, Dorronsoro M, Barricarte A, Cirera L, Quiros JR, Berglund G, Manjer J, Forsberg B, Day NE, Key TJ, Kaaks R, Saracci R, Riboli E. Lung cancers attributable to environmental tobacco smoke and air pollution in non-smokers in different European countries: a prospective study. Environ Health. 2007, 6:7

Rushton L. Workplace and cancer: interactions and updates. Occup Med (Lond). 2009, 59:78-81

Beelen R, Hoek G, van den Brandt PA, Goldbohm RA, Fischer P, Schouten LJ, Jerrett M, Hughes E, Armstrong B, Brunekreef B. Long-term effects of traffic-related air pollution on mortality in a Dutch cohort (NLCS-AIR study). Environ Health Perspect. 2008, 116:196-202

Pope CA 3rd, Ezzati M, Dockery DW. Fine-particulate air pollution and life expectancy in the United States. N Engl J Med. 2009, 360:376-386

Jerrett M, Buzzelli M, Burnett RT, DeLuca PF. Particulate air pollution, social confounders, and mortality in small areas of an industrial city. Soc Sci Med. 2005, 60:2845-2863

Eftim SE, Samet JM, Janes H, McDermott A, Dominici F. Fine particulate matter and mortality: a comparison of the Six Cities and American Cancer Society cohorts with a Medicare cohort. Epidemiology. 2008, 19:209-216

Laden F, Schwartz J, Speizer FE, Dockery DW. Reduction in fine particulate air pollution and mortality: extended follow-up of the Harvard Six Cities Study. Am J Respir Crit Care Med. 2006, 173:667-672

Schwartz J, Coull B, Laden F, Ryan L. The effect of dose and timing of dose on the association between airborne particles and survival. Environ Health perspect. 2008, 116:64-69

Pope CA, 3rd. Mortality effects of longer term exposures to fine particulate air pollution: review of recent epidemiological evidence. Inhal Toxicol. 2007, S19:33-38

Pope CA 3rd, Burnett RT, Thun MJ, Calle EE, Krewski D, Ito K, Thurston GD.Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA. 2002, 287:1132-1141

Jerrett M, Burnett RT, Pope CA 3rd, Ito K, Thurston G, Krewski D, Shi Y, Calle E, Thun M. Long-term ozone exposure and mortality. N Engl J Med. 2009, 360:1085-1095

Jerrett M, Burnett RT, Ma R, Pope CA 3rd, Krewski D, Newbold KB, Thurston G, Shi Y, Finkelstein N, Calle EE, Thun MJ. Spatial analysis of air pollution and mortality in Los Angeles. Epidemiology. 2005, 16:727-736

Abbey DE, Nishino N, McDonnell WF, Burchette RJ, Knutsen SF, Lawrence Beeson W, Yang JX. Long-term inhalable particles and other air pollutants related to mortality in nonsmokers. Am J Respir Crit Care Med. 1999, 159:373-382

Barchana M, Liphshitz I, Rozen P. Trends in colorectal cancer incidence and mortality in the Israeli Jewish ethnic populations. Fam Cancer. 2004, 3;207-214

Unger JB, Sun P, Johnson CA. Socioeconomic correlates of smoking among an ethnically diverse sample of 8th grade adolescents in Southern California. Prev Med. 2007, 44:323-327

Scragg R, Laugesen M, Robinson E. Cigarette smoking, pocket money and socioeconomic status: results from a national survey of 4th form students in 2000. N Z Med J. 2002, 115:108

Shadmi E, Balicer RD, Kinder K, Abrams C, Weiner JP. Assessing socioeconomic health care utilization inequity in Israel: impact of alternative approaches to morbidity adjustment. BMC Public Health. 2011, 11:609

Beeson WL, Abbey DE, Knutsen SF. Long-term concentrations of ambient air pollutants and incident lung cancer in California adults: results from the AHSMOG study. Adventist Health Study on Smog. Environ Health Perspect. 1998, 106:813-822

Nafstad P, Håheim LL, Wisløff T, Gram F, Oftedal B, Holme I, Hjermann I, Leren P. Urban air pollution and mortality in a cohort of Norwegian men. Environ Health Perspect. 2004, 112:610-615

Salerno C, Berchialla P, Palin LA, Vanhaecht K, Panella M. Cancer morbidity of residents living near an oil refinery plant in North-West Italy. Int J Environ Health Res. 2012 Oct 16 (Epub ahead of print)

Yang CY, Cheng MF, Chiu JF, Tsai SS. Female lung cancer and petrochemical air pollution in Taiwan. Arch Environ Health. 1999, 54:180-185

Axelsson G, Barregard L, Holmberg E, Sallsten G. Cancer incidence in a petrochemical industry area in Sweden. Sci Total Environ. 2010, 408:4482-4487

Lyons RA, Monaghan SP, Heaven M, Littlepage BN, Vincent TJ, Draper GJ. Incidence of leukemia and lymphoma in young people in the vicinity of the petrochemical plant at Baglan Bay, South Wales, 1974 to 1991. Occup Environ Med. 1995, 52:225-258

Rottenberg Y, Jacobs JM, Barchana M, Stessman Y. Risks factors for cancer among elderly: The Jerusalem Longitudinal Cohort Study. J Geriatr Oncol. 2010, 2:45-49

Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. 2011, 61:212-236

Cook MB, Dawsey SM, Freedman ND, Inskip PD, Wichner SM, Quraishi SM, Devesa SS, McGlynn KA. Sex disparities in cancer incidence by period and age. Cancer Epidemiol Biomarkers Prev. 2009, 18:1174-1182

Yin D, Morris C, Allen M, Cress R, Bates J, Liu L. Does socioeconomic disparity in cancer incidence vary across racial/ethnic groups? Cancer Causes Control. 2010, 21:1721-1730

Center MM, Jemal A, Ward E. International trends in colorectal cancer incidence rates. Cancer Epidemiol Biomarkers Prev. 2009, 18:1688-1694

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