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Pro-inflammatory Cytokines and Oral Lichen Planus

Narjiss Akerzoul, Saliha Chbicheb

Abstract


Pro-inflammatory Cytokines are powerful mediators which play a central role in both innate and adapted immune responses. Aberrant productions of cytokines may lead to the onset of immune deficiency, allergy or autoimmunity, which are involved in the mechanisms of various immune-mediated inflammatory diseases. Oral lichen planus (OLP) is a chronic inflammation disease affecting the oral mucosa with unknown aetiology. Previous studies have described the abnormal expression patterns of various inflammation-related cytokines, such as IL-1, 2, 4, , 6, 8, 10, 12, 17, 18, TGF- , IFN-  and TNF- , in lesions, saliva, serum and peripheral blood mononuclear cells from patients with OLP, which may reflect the immune dysregulation status and emerge as central players in the immunopathogenesis of OLP. Besides, the gene polymorphisms of several cytokines such as IFN- , TNF- , IL-4, IL-10 have been found to be involved in the susceptibility of OLP. The aim of this paper is to briefly present the characteristics and a current description about the involvement of these pro-inflammatory cytokines in the pathogenesis of OLP leading to understand the eventual malignant transofrmation of OLP to Oral Cancer.


Keywords


Pro-inflammatory Cytokines, Oral Lichen Planus, Malignant Tranformation, Oral Cancer, Interleukines

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