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Correlation of p53 Expression with Different Histological Grades in Oral Squamous Cell Carcinoma Patients from Northern India

Manzoor Ahmad Gatoo, Ayaz Mahmood Dar, Mashiatullah Siddiqui

Abstract


In the present study, out of the total 100 patients studied, 75 patients (75%) were males and majority of patients were in 50-75 age group and complained of dysphagia. It was found that the most common site of incidence of oral cancer in tobacco and betel quid chewers was buccal mucosa. The aim of this study is to further examine the relationship between p53 expression with different histological grades in oral squamous cell carcinoma (OSSC) patients from north India. It was found that there was no p53 expression in normal tissues while in oral SCC patients with tobacco and betel quid chewing habit, the percentage of positive cases as well as p53 positivity showed an increase with increasing grade of SCC. The expression of p53 was significantly associated with histological grade in oral cancer in tobacco and betel quid chewers. In case of p53 expression, statistically significant difference in p53 positivity was observed only on comparing well differentiated SCC with poorly differentiated SCC. The expression of p53 was not similar in different sites of oral cavity but was more frequently seen in gingivia, floor of mouth, tongue, and buccal mucosa.


Keywords


Oral squamous cell carcinoma; p53; betel quid chewers; carcinogens

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