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Re-evaluation of Metaplastic Osteogenesis in the Bovine Lymph Node with Metastatic Cholangiocarcinoma: A Supplemental Report

Susumu Ohfuji

Abstract


Introduction: For deepening knowledge of the developmental process involving metaplastic osteogenesis in extraskeletal tumor, histopathological re-evaluation was conducted on osseous metaplasia in the bovine lymph node with metastatic cholangiocarcinoma, which was previously reported in this journal by the author.

Presentation of Case: In an aged Holstein-Friesian dairy cow that exhibited intrahepatic cholangiocarcinoma with widespread metastasis, a mesenteric lymph node with metastatic cancer had multifocal areas of osseous metaplasia. Abundant stromal connective tissue of the metastatic cancer showed prominent proliferation of capillaries and mesenchymal cells. There were no definite transitional features between mesenchymal cells associated with bone tissue and cancer cells. A variety of stages toward differentiating into osseous component included occurrence of (1) focal areas of dense collagen fibers accompanied by many mesenchymal cells, (2) osteoid surrounded by a single to multilayer of osteoblasts, (3) trabeculae of woven bone containing many osteocytes, and (4) bone resorption associated with osteoclastic activity in more differentiated bone trabeculae. These findings suggested that osseous metaplasia might have developed through the process identical to intramembranous ossification, as seen in flat bone formation in the developing fetus. Furthermore, this metaplastic osteogenesis was associated with the process involving the coordinated activities of osteoblasts and osteoclasts, as seen in remodeling of bone tissue throughout postnatal life.

Conclusion: Although metaplastic bone did not fully differentiated into mature bone, the pathway of metaplastic osteogenesis might have followed the developmental stages identical, to some degree, to the process that controls skeletal maturation and remodeling.


 


Keywords


Bovine; lymph node; metaplastic osteogenesis; metastatic cancer

References


Mukonoweshuro P, Oriowolo A. Stromal osseous metaplasia in a low-grade ovarian adenocarcinoma. Gynecol Oncol. 2005, 99:222-224

Miliaras D, ketikidou M, Pervana S. Osseous metaplasia in ovarian tumors: a case with serous cystadenoma. J Clin Pathol. 2007, 60:582-583

Kefeli M, Yildiz L, Aydin O, Kandemir B, Faik Yilmaz A. Chromophobe renal cell carcinoma with osseous metaplasia containing fatty bone marrow element: a case report. Pathol Res Pract. 2007, 203:749-752

Murugan P, Basu D, Manikandan R, Dorairajan LN, Kumar S. Osseous metaplasia in renal cell carcinoma: report of a rare case. Indian J Pathol Microbiol. 2008, 51:399-401

Mege-Lechevallier F, Cherasse A, Monze S, Colombel M, Scoazec JY. Transitional carcinoma of the ureter with osseous metaplasia of the stroma: a case report. Ann Pathol. 2007, 27:43-46

Ninomiya J, Oyama T, Horiguchi J, Koibuchi Y, Yoshida T, Iijima K, Yoshida M, Tanaka D, Iino Y. Two case of breast cancer with cartilaginous and osseous metaplasia. Breast Cancer. 2005, 12:52-56

Katase N, Tamamura R, Gunduz M, Murakami J, Asaumi J, Tsukamoto G, Sasaki A, Nagatsuka H. A spindle cell carcinoma presenting with osseous metaplasia in the gingiva: a case with immunohistochemical analysis. Head Face Med. 2008, 4:28

Al-Daraji WI, Abdellaoui A, Salman WD. Osseous metaplasia in a tubular adenoma of the colon. J Clin Pathol. 2005, 58:220-221

White V, Shaw AG, Tierney GM, Lund JL, Semeraro D. Osseous metaplasia in an ulcerating tubular adenoma of the colon: a case report. J Med Case Rep. 2008, 2:130-134

Ozkanli S, Yildirim A, Zemheri E, Keskin SK, Basok EK. Osseous metaplasia and bone marrow elements in a case of renal cell carcinoma. Case Rep Urol. 2012, 2012:3

Kypson AP, Morphew E, Jones R, Gottfried MR, Seigler HE. Heterotopic ossification in rectal cancer: rare finding with a novel proposed mechanism. J Surg Oncol. 2003, 82:132-136

Marioni G, Altavilla G, Marino F, Marchese-Ragona R, Lelli-Mami G, Staffieri A. Squamous cell carcinoma of the larynx with osteosarcoma-like stromal metaplasia. Acta Otolaryngol. 2004, 124:870-873

Meyer PN, Al-Masri H, Alkan S. Osseous metaplasia in diffuse large B-cell lymphoma. Am J Hematol. 2007, 82:321-324

Tsukuda K, Tsuji H, Kunitomo T, Aokage K, Miyake T, Nakahara S, Masuda H. Breast cancer with cartilaginous and/or osseous metaplasia diagnosed by lymph nodal metastasis: a case report. Acta Med Okayama. 2009, 63:367-371

Cormio L, Sanguedolce F, Massenio P, Di Fino G, Selvaggio O, Bufo P, Carrieri G. Osseous metaplasia within an urothelial bladder cancer nodal metastasis: a case report. Anal Quant Cytopathol Histopathol. 2014, 36:117-119

Haddad FS, Shah IA, Manne RK, Costantino JM, Somsin AA. Renal cell carcinoma insulated in the renal capsule with calcification and ossification. Urol Int.1993, 51:97-101

Garin JM, Marco I, Salva A, Serrano F, Bondia JM, Pacheco M. CT and MRI in fat-containing papillary renal cell carcinoma. British J Radiol. 2007, 80:193-195

Kannegieter NJ, Schaaf KL, Lovell DK, Simon CD, Stone BM. Myofibroblastic fibrosarcoma with multifocal osseous metaplasia at the site of equine influenza vaccination. Aust Vet J. 2010, 88:132-136

Rottman JB, Roberts MC, Cullen JM. Colonic adenocarcinoma with osseous metaplasia in a horse. J Am Vet Med Assoc. 1991, 198:657-659

Kornegay RW, Morris JM, Cho D, Lozano-Alarcon F. Pancreatic adenocarcinoma with Osseous metaplasia in a ferret. J Comp Pathol. 1991, 105:117-121

Bangari DS, Stevenson GW. Carcinoma in a mixed mammary tumor in a llama (Lama glama). J Vet Diagn Invest. 2007, 19:450-453

Sant’Ana FJ, Serakides R, Graça DL. Pilocytic astocytoma in a cat. Vet Pathol. 2002, 39:759-761

Park JK, Lee SK, Park SJ, Hong IH, Jeong KS. Fibroma with osseous metaplasia of external auditory canal in a dog. J Vet Diagn Invest. 2010, 22:635-638

Ramirez GA, Altimira J, Garcia B, Vilafranca M. Chondro-osteoblastic metaplasia in canine benign cutaneous lipomas. J Comp Pathol. 2010, 142:89-93

Pool RR, Thompson KG. Tumors in joints. In: Meuten DJ ed. Tumors in Domestic Animals. Ames: Iowa State Press, 2002: 199-243

Ohfuji S. Osseous metaplasia in the mesenteric lymph node with metastatic cholangiocarcinoma in a cow. Am J Cancer Sci. 2012, 1:1-7

Blechacz B, Gores GJ. Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment. Hepatol. 2008, 48:308-321

Tyson GI, El-Serag HB. Risk factors for cholangiocarcinoma. Hepatol. 2011, 54:173-184.

Braconi, C., Patel, T. Cholangiocarcinoma: new insights into disease pathogenesis and biology. Infect Dis Clin North Am. 2010, 24:871-884

Adams SZ, Parthasarathy S, Miller FH. Intrahepatic cholangiocarcinomas mimicking other lesions. Abdom Imaging. 2015, 40:2345-2354

Anderson LJ, Sandison AT. Tumors of the liver in cattle, sheep and pigs. Cancer. 1968, 21:289-301

Cullen JM, Popp JA. Cholangiocarcinoma. In: Meuten DJ ed. Tumors in Domestic Animals. Ames: Iowa State Press, 2002: 495-499

Bettini G, Marcato PS. Primary hepatic tumours in cattle. A classification of 66 cases. J Comp Pathol. 1992, 107:19-34

Ramos-Vara JA, Miller MA, Johnson GC. Immunohistochemical characterization of canine hyperplastic hepatic lesions and hepatocellular and biliary neoplasms with monoclonal antibody hepatocyte paraffin 1 and a monoclonal antibody to cytokeratin 7. Vet Pathol. 2001, 38:636-643

Ohfuji S. Cholangiocarcinoma of possibly hepatic progenitor cell origin in a cow. Vet Q. 2012, 32:183-186

Thompson K. Structure and function of bone tissue. In: Maxie MG ed. Jubb, Kennedy, and

Palmer’s Pathology of Domestic Animals. Edinburgh: Elsevier Saunders, 2007: 2-24

Liotta LA, Kohn EC. The microenvironment of the tumour-host interface. Nature. 2001, 411:375-379

Noel A, Jost M, Maquoi E. Matrix metalloproteinase at cancer tumor-host interface. Semin Cell Dev Biol. 2008, 19:52-60

Voutouri C, Mpekris F, Papageorgis P, Odysseos AD, Stylianopoulos T. Role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors. PLoS ONE. 2014, 9

Gunasegaran JP. Textbook of Histology and a Practical Guide. 1st ed. Haryana: Elsevier, 2007: 71-91

Bilezikian JP, Raisz LG, Rodan GA. Principles of Bone Biology. 2nd ed. San Diego: Academic Press, 2002: 3-16, 919-928

Wozney JM, Rosen V. Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair. Clin Orthop Relat Res. 1998, 346:26-37


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