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Cytogenetics and FISH Studies in Multiple Myeloma – A Retrospective Study from Western India

Pankaj K. Gadhia, Salil Vaniawala


Multiple myeloma is characterized by a complex pattern of extensive genomic aberrations involving many chromosomes and it constitutes about 1% of all malignancies. We have performed conventional cytogenetic (CC) and interphase FISH on 58 cases of MM. Results showed that from 58 cases, only 08 cases had abnormal karyotype by conventional cytogenetic. On the other hand, interphase FISH study with 58 MM patients revealed 08 patients with normal results while 50 patients showed complex genetic aberrations. It included deletions of 13q14 (48.3%), 17p13 (13.8%), 11q13 (27.6%) along with translocation of IgH involving t(4;14)(51.7%) and t(14;16)(1,7%). We conclude that interphase FISH study should be performed in conjunction with conventional cytogenetic for prognostic significance in MM.


Multiple myeloma; Bone marrow; G-banding, Karyotyping; FISH


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