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Influence of Sulfonylurea and Insulin on Immunological Profile of Type 2 diabetic Egyptian Patients

Zeinab Saied, Azza El Amir, Hisham EL Hefnawy, Ahmed Afifi


Type 2 diabetes mellitus (T2DM) is a chronic, inflammatory disease caused by long-term imbalance in immune system, metabolic syndrome, or nutrient excess associated with obesity .Sulfonylurea and exogenous insulin have been used in the treatment of T2DM, and they have hypoglycemic and anti-inflammatory effects .The aim of this study to demonstrate the effect of sulfonylurea and exogenous insulin on some immunological parameters in Egyptian patients with T2DM and determine whether diabetes or the type of treatment would influence the levels of these parameters.

Materials &Methods: This study was performed on 150 outpatients with type 2 diabetes matched with age and gender with 40 healthy subjects was selected from the outpatient’s clinics of National Institute for Diabetes and Endocrinology. All studied patients and control were subjected to estimate Fasting blood glucose (FBG), Glycosylated heamoglobulin (HBA1c), White blood cells (WBCs), Interleukin-6(IL-6), Immunoglobulin G (IgG) and Immunoglobulin A (IgA). Results: The levels of FBG, HBA1c, WBCs, IL-6, IgG and IgA showed highly significant increase in the diabetic patient groups compared to controls. (P˂0.001).Treatment of T2DM patients with sulfonylurea and insulin caused highly significant decrease in the levels of FBG, HBA1c as compared to corresponding non -treated group (P˂0.001). Also, the level of IL-6 revealed a highly significant decrease in insulin treated patients  as compared to corresponding non -treated group(p<0.001).While, non-significant change (p>0.05) in the levels of WBCs, IgG and IgA was observed in treated patient groups with sulfonylureas and insulin as compared to corresponding non -treated group.

Conclusion: Both sulfonylurea and insulin are immune- safe therapeutic agent in T2DM at dose achieve good glycemic control.




Type 2 diabetes; Sulfonylurea; Insulin; Immunoglobulin; IL-6


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