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HBA1C Levels, Lipid Profile and Thyroid Profile in Patients Admitted with Severe Hypoglycemia in Type 2 Diabetes Mellitus

Sreenivasa rao sudulagunta, Shiva Kumar B.R., Mahesh Babu Sodalagunta, Hadi Khorram, Mona Sepehrar, Zahra Noroozpour


Objective: We studied the association between HbA1c level, Lipid profile and Thyroid profile in patients admitted with hypoglycemia in type 2 diabetes mellitus. Materials and methods: Patients admitted with severe hypoglycemia (<50mg/dl) are included in this observational study from 4 hospitals from January 2013 till January 2015. HBA1C, Lipid profile and Thyroid profile recorded during admission are the points of interest in this study. Demographic and clinical variables were recorded to evaluate the relative risk (RR) of severe hypoglycemia across HbA1c levels. We also studied comorbidities associated with DM. Results: Among 1200 patients enrolled, mean age was 58.6±11.7 years. 83% of patients were above 50 years of age of which 50% were in 50-59 years age group. Mean Glycated hemoglobin was 8.3±2.09. Patients admitted with hypoglycemia constitute 118(9.83%), 64(5.33%), 200 (16.6%), 624(52%) and 194(16.16%) in HbA1c categories <6, 6–6.9, 7–7.9, 8–8.9, and >9% which is statistically significant (P value<0.01). Abnormal lipid profile was found in 96.5 %( 1158) of the study population and abnormal Thyroid profile in 11.6%. Conclusions: Hypoglycemia can occur at any level of glycated Hemoglobin but high risk is found with HBA1c of <6% and >8%. Elderly population should not be subjected for stricter control of blood sugars which can do more harm than good. Patients with mean duration of diabetes more than 10 years are at higher risk of recurrent hypoglycemia.


Glycated Hemoglobin (HBA1c); Thyroid profile; Chronic Kidney disease (CKD); Ischemic Heart disease (IHD); Hypoglycemia; Dyslipidemia


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