Omar Cauli

Omar Cauli
University of Valencia, Spain

PhD, Professor,

Department of Nursing.


1. Agusti A, Cauli O, Rodrigo R, Llansola M, Hernandez-Rabaza V, Felipo V. P38 map kinase is a therapeutic target for hepatic encephalopathy in rats with portacaval shunts. Gut. 2011, 60:1572-1579

2. Boix J, Cauli O. Alteration of serotonin system by polychlorinated biphenyls exposure. Neurochemistry International. 2012, 60:809-816

3. Boix J, Cauli O, Leslie H, Felipo V. Differential long-term effects of developmental exposure to polychlorinated biphenyls 52, 138 or 180 on motor activity and neurotransmission. Gender dependence and mechanisms involved. Neurochemistry International. 2011, 58:69-77

4. Boix J, Lansola M, Cauli O, Agusti A, Vicente F. Effects of developmental exposure to different ndl-pcb congeners on cognitive and motor function. Possible underlying mechanisms. Ndl-pcbs session. Toxicology Letters. 2009, 189:S101-S101

5. Brunelli L, Campagna R, Airoldi L, Cauli O, Llansola M, Boix J, Felipo V, Pastorelli R. Exploratory investigation on nitro- and phospho-proteome cerebellum changes in hyperammonemia and hepatic encephalopathy rat models. Metabolic Brain Disease. 2012, 27:37-49

6. Canales JJ, Elayadi A, Errami M, Llansola M, Cauli O, Felipo V. Chronic hyperammonemia alters motor and neurochemical responses to activation of group i metabotropic glutamate receptors in the nucleus accumbens in rats in vivo. Neurobiology of Disease. 2003, 14:380-390

7. Carta AR, Pinna A, Cauli O, Morelli M. Differential regulation of gad67, enkephalin and dynorphin mrnas by chronic-intermittent l-dopa and a(2a) receptor blockade plus l-dopa in dopamine-denervated rats. Synapse. 2002, 44:166-174

8. Cauli O. Gender differences in neurotoxicity. Toxicology. 2013, 311:1-2

9. Cauli O, Llansola M, Erceg S, Felipo V. Hypolocomotion in rats with chronic liver failure is due to increased glutamate and activation of metabotropic glutamate receptors in substantia nigra. Journal of Hepatology. 2006, 45:654-661

10. Cauli O, Llansola M, Rodrigo R, El Mlili N, Errami M, Felipo V. Altered modulation of motor activity by group i metabotropic glutamate receptors in the nucleus accumbens in hyperammonemic rats. Metabolic Brain Disease. 2005, 20:347-358

11. Cauli O, Lopez-Larrubia P, Rodrigo R, Agusti A, Boix J, Nieto-Charques L, Cerdan S, Felipo V. Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats. Gastroenterology. 2011, 140:638-645

12. Cauli O, Lopez-Larrubia P, Rodrigues TB, Cerdan S, Felipo V. Magnetic resonance analysis of the effects of acute ammonia intoxication on rat brain. Role of nmda receptors. Journal of Neurochemistry. 2007, 103:1334-1343

13. Cauli O, Mansouri MT, Agusti A, Felipo V. Hyperammonemia increases gabaergic tone in the cerebellum but decreases it in the rat cortex. Gastroenterology. 2009, 136:1359-1367

14. Cauli O, Mlili N, Llansola M, Felipo V. Motor activity is modulated via different neuronal circuits in rats with chronic liver failure than in normal rats. European Journal of Neuroscience. 2007, 25:2112-2122

15. Cauli O, Mlili N, Rodrigo R, Felipo V. Hyperammonaemia alters the mechanisms by which metabotropic glutamate receptors in nucleus accumbens modulate motor function. Journal of Neurochemistry. 2007, 103:38-46

16. Cauli O, Morelli M. Subchronic caffeine administration sensitizes rats to the motor-activating effects of dopamine d-1 and d-2 receptor agonists. Psychopharmacology. 2002, 162:246-254

17. Cauli O, Piedrafita B, Llansola M, Felipo V. Gender differential effects of developmental exposure to methyl-mercury, polychlorinated biphenyls 126 or 153, or its combinations on motor activity and coordination. Toxicology. 2013, 311:61-68

18. Cauli O, Pinna A, Morelli M. Subchronic intermittent caffeine administration to unilaterally 6-hydroxydopamine-lesioned rats sensitizes turning behaviour in response to dopamine d-1 but not d-2 receptor agonists. Behavioural Pharmacology. 2005, 16:621-626

19. Cauli O, Pinna A, Valentini V, Morelli M. Subchronic caffeine exposure induces sensitization to caffeine and cross-sensitization to amphetamine ipsilateral turning behavior independent from dopamine release. Neuropsychopharmacology. 2003, 28:1752-1759

20. Cauli O, Rodrigo R, Boix J, Piedrafita B, Agusti A, Felipo V. Acute liver failure-induced death of rats is delayed or prevented by blocking nmda receptors in brain. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2008, 295:G503-G511

21. Cauli O, Rodrigo R, Llansola M, Montoliu C, Monfort P, Piedrafita B, el Mlili N, Boix J, Agusti A, Felipo V. Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy. Metabolic Brain Disease. 2009, 24:69-80

22. Cauli O, Rodrigo R, Piedrafita B, Boix J, Felipo V. Inflammation and hepatic encephalopathy: Ibuprofen restores learning ability in rats with portacaval shunts. Hepatology. 2007, 46:514-519

23. Cauli O, Rodrigo R, Piedrafita B, Llansola M, Mansouri MT, Felipo V. Neuroinflammation contributes to hypokinesia in rats with hepatic encephalopathy: Ibuprofen restores its motor activity. Journal of Neuroscience Research. 2009, 87:1369-1374

24. Cocco MT, Congiu C, Onnis V, Morelli M, Cauli O. Synthesis of ibuprofen heterocyclic amides and investigation of their analgesic and toxicological properties. European Journal of Medicinal Chemistry. 2003, 38:513-518

25. Cocco MT, Congiu C, Onnis V, Morelli M, Felipo V, Cauli O. Synthesis of new 2-arylamino-6-trifluoromethylpyridine-3-carboxylic acid derivatives and investigation of their analgesic activity. Bioorganic & Medicinal Chemistry. 2004, 12:4169-4177

26. El-Mlili N, Rodrigo R, Naghizadeh B, Cauli O, Felipo V. Chronic hyperammonemia reduces the activity of neuronal nitric oxide synthase in cerebellum by altering its localization and increasing its phosphorylation by calcium-calmodulin kinase ii. Journal of Neurochemistry. 2008, 106:1440-1449

27. Erceg S, Monfort P, Cauli O, Montoliu C, Llansola M, Piedrafita B, Felipo V. Role of extracellular cgmp and of hyperammonemia in the impairment of learning in rats with chronic hepatic failure - therapeutic implications. Neurochemistry International. 2006, 48:441-446

28. Fenu S, Cauli O, Morelli M. Cross-sensitization between the motor activating effects of bromocriptine and caffeine: Role of adenosine a2a receptors. Behavioural Brain Research. 2000, 114:97-105

29. Garcia-Ayllon M-S, Cauli O, Silveyra M-X, Rodrigo R, Candela A, Compan A, Jover R, Perez-Mateo M, Martinez S, Felipo V, Saez-Valero J. Brain cholinergic impairment in liver failure. Brain. 2008, 131:2946-2956

30. Gonzalez-Usano A, Cauli O, Agusti A, Felipo V. Hyperammonemia alters the modulation by different neurosteroids of the glutamate-nitric oxide-cyclic gmp pathway through nmda-gaba(a)- or sigma receptors in cerebellum in vivo. Journal of Neurochemistry. 2013, 125:133-143

31. Herraiz S, Pellicer B, Cauli O, Rodrigo R, Felipo V, Simon C, Pellicer A. Pre- and postnatal brain damage in preeclamptic animal model induced by gestational nitric oxide synthase inhibition. Reproductive Sciences. 2010, 17:129A-129A

32. Jover R, Rodrigo R, Felipo V, Insausti R, Saez-Valero J, Garcia-Ayllon MS, Suarez I, Candela A, Compan A, Esteban A, Cauli O, Auso E, Rodriguez E, Gutierrez A, Girona E, Erceg S, Berbel P, Perez-Mateo M. Brain edema and inflammatory activation in bile duct ligated rats with diet-induced hyperammonemia: A model of hepatic encephalopathy in cirrhosis. Hepatology. 2006, 43:1257-1266

33. Llansola M, Montoliu C, Cauli O, Hernandez-Rabaza V, Agusti A, Cabrera-Pastor A, Gimenez-Garzo C, Gonzalez-Usano A, Felipo V. Chronic hyperammonemia, glutamatergic neurotransmission and neurological alterations. Metabolic Brain Disease. 2013, 28:151-154

34. Llansola M, Rodrigo R, Monfort P, Montoliu C, Kosenko E, Cauli O, Piedrafita B, El Mlili N, Felipo V. Nmda receptors in hyperammonemia and hepatic encephalopathy. Metabolic Brain Disease. 2007, 22:321-335

35. Llansola M, Sanchez-Perez A, Cauli O, Felipo V. Modulation of nmda receptors in the cerebellum. 1. Properties of the nmda receptor that modulate its function. Cerebellum. 2005, 4:154-161

36. Lopez-Larrubia P, Cauli O. Alterations of apparent diffusion coefficient (adc) in the brain of rats chronically exposed to lead acetate. Toxicology. 2011, 281:1-6

37. Mansouri MT, Cauli O. Motor alterations induced by chronic lead exposure. Environmental Toxicology and Pharmacology. 2009, 27:307-313

38. Mansouri MT, Naghizadeh B, Lopez-Larrubia P, Cauli O. Behavioral deficits induced by lead exposure are accompanied by serotonergic and cholinergic alterations in the prefrontal cortex. Neurochemistry International. 2013, 62:232-239

39. Monfort P, Cauli O, Montoliu C, Rodrigo R, Llansola M, Piedrafita B, el Mlili N, Boix J, Agusti A, Felipo V. Mechanisms of cognitive alterations in hyperammonemia and hepatic encephalopathy: Therapeutical implications. Neurochemistry International. 2009, 55:106-112

40. Monfort P, Munoz MD, Kosenko E, Llansola M, Sanchez-Perez A, Cauli O, Felipo V. Sequential activation of soluble guanylate cyclase, protein kinase g and cgmp-degrading phosphodiesterase is necessary for proper induction of long-term potentiation in ca1 of hippocampus alterations in hyperammonemia. Neurochemistry International. 2004, 45:895-901

41. Montoliu C, Cauli O, Urios A, ElMlili N, Serra MA, Giner-Duran R, Gonzalez-Lopez O, Del Olmo JA, Wassel A, Rodrigo JM, Felipo V. 3-nitro-tyrosine as a peripheral biomarker of minimal hepatic encephalopathy in patients with liver cirrhosis. American Journal of Gastroenterology. 2011, 106:1629-1637

42. Montoliu C, Rodrigo R, Monfort P, Llansola M, Cauli O, Boix J, ElMlili N, Agusti A, Felipo V. Cyclic gmp pathways in hepatic encephalopathy. Neurological and therapeutic implications. Metabolic Brain Disease. 2010, 25:39-48

43. Pascual M, Blanco AM, Cauli O, Minarro J, Guerri C. Intermittent ethanol exposure induces inflammatory brain damage and causes long-term behavioural alterations in adolescent rats. European Journal of Neuroscience. 2007, 25:541-550

44. Piedrafita B, Cauli O, Montoliu C, Felipo V. The function of the glutamate-nitric oxide-cgmp pathway in brain in vivo and learning ability decrease in parallel in mature compared with young rats. Learning & Memory. 2007, 14:254-258

45. Piedrafita B, Erceg S, Cauli O, Monfort P, Felipo V. Developmental exposure to polychlorinated biphenyls pcb153 or pcb126 impairs learning ability in young but not in adult rats. European Journal of Neuroscience. 2008, 27:177-182

46. Piedrafita B, Monfort P, Cauli O, Llansola M, Rodrigo R, Montoliu C, El Mlili N, Felipo V. Mechanisms of developmental neurotoxicity: Molecular and behavioral correlates. Toxicology Letters. 2006, 164:S24-S25

47. Ponsati B, Carreno C, Curto-Reyes V, Valenzuela B, Jose Duart M, Van den Nest W, Cauli O, Beltran B, Fernandez J, Borsini F, Caprioli A, Di Serio S, Veretchy M, Baamonde A, Menendez L, Barros F, de la Pena P, Borges R, Felipo V, Planells-Cases R, Ferrer-Montiel A. An inhibitor of neuronal exocytosis (dd04107) displays long-lasting in vivo activity against chronic inflammatory and neuropathic pain. Journal of Pharmacology and Experimental Therapeutics. 2012, 341:634-645

48. Rodrigo R, Cauli O, Boix J, ElMlili N, Agusti A, Felipo V. Role of nmda receptors in acute liver failure and ammonia toxicity: Therapeutical implications. Neurochemistry International. 2009, 55:113-118

49. Rodrigo R, Cauli O, Gomez-Pinedo U, Agusti A, Hernandez-Rabaza V, Garcia-Verdugo J-M, Felipo V. Hyperammonemia induces neuroinflammation that contributes to cognitive impairment in rats with hepatic encephalopathy. Gastroenterology. 2010, 139:675-684

50. Rodrigo R, Monfort P, Cauli O, Erceg S, Felipo V. Pharmacological manipulation of cyclic gmp levels in brain restores learning ability in animal models of hepatic encephalopathy: Therapeutic implications. Neuropsychiatric disease and treatment. 2006, 2:53-63

51. Sanchez-Perez A, Llansola M, Cauli O, Felipo V. Modulation of nmda receptors in the cerebellum. Ii. Signaling pathways and physiological modulators regulating nmda receptor function. Cerebellum. 2005, 4:162-170

52. Simola N, Cauji O, Morelli M. Sensitization to caffeine and cross-sensitization to amphetamine: Influence of individual response to caffeine. Behavioural Brain Research. 2006, 172:72-79