Epidemiology and Clinical Profile of Gloriosa Superba Poisoning in Sri Lanka
Introduction: Gloriosa superba is a common plant poisoning in Sri Lanka which has fatal outcomes. Except few case reports, there are no systematic studies regarding its poisoning in the country. The objective of this study was to describe epidemiological and clinical manifestations following Gloriosa superba poisoning and its long term effects.
Methods: A descriptive observational study involving a series of 33 patients with Gloriosa superba poisoning was conducted for one year duration commencing from July 2015.
Results: Twenty-nine (87.87%) cases were deliberate self-poisonings and 4 (12.12%) were accidental poisonings. Females were 21 (63.63%) and males were 12 (36.36%). Their age ranged from 13 years to 72. Thirty (90.9%) ingested Gloriosa tubers. Five patients (15.15%) died due to Gloriosa poisoning. Thirty one patients (93.93%) developed acute gastrointestinal symptoms; 7 (21.21%) had cardiotoxic effects; 3 (9%) developed respiratory failure; 5 (15.15%) had neurological and bleeding manifestations; 2 (6%) had acute kidney injury. Hypokalaemia was observed in 16 (48.48%), leucopenia in 5 (15.15%) and anaemia in 4 (12.12%) patients. Alopecia was observed in 4 (12.12%) patients as the long term effect.
Conclusion: There is a multi-organ system involvement in Gloriosa superba poisoning such as gastrointestinal tract, heart, lungs, kidneys, brain, liver and haemopoietic system.
Aleem HM. Gloriosa superba poisoning. Journal of the Association of Physicians of India. 1992, 40(8):541-542
Angunawela RM, Fernando HA. Acute ascending polyneuropathy and dermatitis following poisoning by tubers of Gloriosa superba. Ceylon Medical Journal. 1971, 16:233-235
Babu RYP, Manjunath S, Bakkannavar SM, Acharya J, Pramod Kumar GN. Colchicine poisoning: a case report and review of literature.Medicine, Science and the Law. 2012, 52:205-206
Basak UC, Dash D, Mahapatra AK. Estimation of Colchicine in Tubers of Gloriosa superba L. Originated From Different Agroclimatic Zones of Odisha, India. International Journal of Pharmacognosy and Phytochemical Research. 2012, 4(3):157-161
Danel VC, Jean-Francois, Wiart D. Self-Poisoning with Colchicum autumnale L. Flowers. Clinical Toxicology. 2001, 39(4):409-411
Dunuwille R, Balasubramanium K and Bibile SW. Analysis of alkaloids in Gloriosa superba. Ceylon J Med Sci. 1968, 17:1
Ellwood MG, Robb GH. Self-poisoning with colchicine. Postgraduate Medical Journal. 1971, 2(47):129-138
Ertuğrul, İlker, Polat, Emine et al. Acute colchicine intoxication complicated with complete AV block. Turkish Journal of Pediatrics . 2015, 57(4):398-400
Fernando R and Widyaratna D. Gloriosa superba. INCHEM. International Programme on Chemical Safety (IPCS). 1989
Fernando R, Fernando D. Poisoning with plants and mushrooms in Sri Lanka: a retrospective hospital based study. Vet Hum Toxicol. 1990, 32:579-581
Folpini A, Furfori P. Colchicine toxicity: clinical features and treatment: massive overdose case report. Clin Toxicol. 1995, 33:71-77
George P. Death related to Herbal Therapy for Joint Pains -A rare case of Gloriossa superba Poisoning. Journal of Clinical and Diagnostic Research. 2011, 5(2):379-380
Gooneratne BWM. Massive generalized alopecia after poisoning by Gloriosa superba. British Medical Journal. 1966, 1:1023-1024
Gooneratne IK. Weeratunga P., Caldera M., Gamage R. Toxic encephalopathy due to colchicines - Gloriosa superba poisoning. Pract Neurol. doi:10.1136/ practneurol-2013-000753
Labib S, Boujraf S, Berdai A, Harandou M. Fatal colchicine intoxication. Saudi J Anaesth. 2014, 8:394-5. doi:10.4103/1658-354X.136629
Maroyi A,Van der Maesen LJG. Gloriosa superba L.(family Colchicaceae): Remedy or poison? Journal of Medicinal Plants Research. 2011, 5(26)6112-6121
Maxwell MJ, Muthu P, PrittyPE. Accidental colchicine overdose. A case report and literature review. Emerg. Med. J. 2002, 19:265-266
Mendis S. Colchicine cardiotoxicity following ingestion of Gloriosa superba tubers. Postgraduate Medical Journal. 1989, 65(768):752-755
Nada Brnèiæ, Ivica Viškoviæ, Relja Periæ et al. Accidental Plant Poisoning with Colchicum autumnale: Report of Two Cases. Croat Med J. 2001, 42:673-675
Namal Rathnayaka RMMK, Jeganadan K, Dissanayake HDMSK, Ranathunga PEAN. Death due to poisoning with Gloriosa superba (‘Niyagala’) seeds. Journal of the Postgraduate Institute of Medicine. 2016, 3:E26:1-3
Prabhu G, Umalakshmi V, Arun M. Clinical profile and outcome of Gloriosa superba poisoning. Indian Journal of Research. 2016, 5:8
Premaratna R, Weerasinghe MS, Premawardana NP, de Silva HJ. Gloriosa superba poisoning mimicking an acute infection- a case report. BMC Pharmacol Toxicol. 2015, 16:27
Samanta AK, Kumar KU. Poisoning by Glory Lily-A case report. JIAFM. 2005, 27(3). ISSN 0971-0973
Stapczynski JS, Rothstein RJ, Gaye WA, Niemann JT. Colchicine overdose: report of two cases and review of the literature. Ann Emerg Med. 1981, 10:364-369
Subbaratnam AV. Studies in the alkaloidal constituents of Gloriosa superba Linn.J. scient. hid. Res. 1954, 13B:670-671
Vidanalage KCJ, Ekanayeka R, Wijewardane DK. A rare case of attempted homicide with Gloriosa superba seeds. BMC Pharmacology and Toxicology. 2016, 17:26
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