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Mitigatory Effects of Quercetin on Bisphenol A-Induced Oxidative Stress in Testis of Swiss Albino Mice

Sanman Samova, Hetal Doctor, R.J. Verma

Abstract


Background: Bisphenol A is a well-known xenoestrogen, mainly used in plastics and food can liners manufacture. Hence, it becomes an integral part of the food chain. Experimental studies shows negative health effects. Quercetin is one of the most effective antioxidants of the flavonoids, generally present in food stuff. The present study was an attempt to assess the mitigatory effects of quer on BPA–induced reduction in fertility of mice.

Materials and methods: Inbred male Swiss strain albino mice were orally administered with various doses of BPA for 45 days. In another experiment quer along with high dose of BPA was administered to study the mitigatory consequence.

Result: Administration of BPA caused significant (P<0.05) and dose-dependent increase in oxidative stress compared to control groups. Administration of quer along with high dose of BPA caused amelioration in enzymatic and non-enzymatic antioxidant. Histopathological alteration was also seen in BPA treated groups, which were ameliorated on administration of quer.

Conclusion: Quer is potent enough to mitigate the toxic effect of BPA. Biochemical alteration was mitigated by quer and dose dependent increase in fertility was observed.


Keywords


Quercetin; Bisphenol A (BPA); Sub chronic toxicity; Oxidative stress; Amelioration

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