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Evaluation Of Platelet-Rich Plasma Effect On Treatment Of Temporomandibular Joint Anterior Disc Displacement

Mustafa Galal Khallaf, Andrew J. Sidebottom, Hussien farouk Elrawy, Mohamed Salah Elmasry


The use of Platelet-Rich-Plasma (PRP) may provide a new and improved treatment option for early and late  Temporomandibular Joint (TMJ) disc displacement. However, there are no long-term studies on its use in TMJ arthritis in the literature. The present study evaluate 28 patients with different degrees of disc displacement over a period of time. These patients had experienced no pain reduction following conservative approaches (including splint therapy) and  minimally invasive arthrocentesis treatment. All patients had evidence of disc displacement associated with pain and discomfort, and sometimes clicking. The patients were without systemic joint disease, septicarthritis, or autoimmune arthritis. Only patients who had not responded to conservative therapy were included in the present study. Pain intensity was recorded for each patient using a 0-10 VAS scale. Maximum Inter-incisal Opening (MIO) was also recorded. This assessment was performed at the pretreatment stage and then examinations 3,6,9,12 months respectively after administration of two intra-articular injections of autologous PRP.The results after 12 months revealed that intra-articular injection of autologous PRP appeared to be an effective treatment method for patients with disc displacement in this study. At the 12-months follow-up, all patients  improved their mouth opening significantly. The majority of the PRP patients  showed decreased pain. The average pain score before PRP administration was 7.5, while 3 months after PRP administration the pain score was 4.2. The pain score continued to decrease, reaching nearly 2 after 6 months and  0.5 by the end of 12 months. In conclusion, the use of PRP was found to be an effective and predictable treatment option for disc displacement.


Platelet-rich plasma; Temporomandibular joint; disc displacement

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