Development, Characterization of Hydroxyl Terminated Dendritic Macromolecules as Prospective Drug Carriers
Abstract
The principal aspiration is to develop triazine dendrimers as potential drug carriers for sustained release. Triazine based dendrimer was synthesized by divergent method evading protection/ deprotection or functional group interconversion. Synthesized dendrimers were characterized by FTIR, 1H-NMR, 13C-NMR and ESI-Mass spectrometry. Synthesized full generation dendrimers G1, G2 and G3 were applied as solubility enhancers of hydrophobic drug ketoprofen. Ketoprofen was loaded by G3 dendrimer by inclusion complex method. Sustained release of ketoprofen from ketoprofen loaded dendrimer was studied and compared to of free ketoprofen. Cytotoxicity and hemolytic assay of dendrimer was studied to evaluate toxicity of dendrimer as drug vehicle.
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References
Gupta U, Aghashe HB, Asthana A, Jain, NK. Dendrimers: Novel Polymeric Nanoarchitectures for Solubility Enhancement. Biomacromol. 2006, 7: 649-658
Karkan M, Li L, Muller RH. Overcoming the challenge of poor drug solubility. Pharm Engg. 2012, 32:1-7
Dhandapani NV, Thapa A, Sandip G, Shrestha A, Shrestha N, Bhattarai RS. Liposomes as novel drug delivery system: A comprehensive review. Int J Res Pharm Sci. 2013, 4(2): 187-193
Fung LK, Saltzman WM. Polymeric implants for cancer chemotherapy. Adv Drug Deliv Rev. 1997, 26(2-3); 209-230
Patel H, Patel PM. Dendrimer Applications a review. Int J Pharma Bio Sci. 2013, 4: 454-463
Patel RM, Gajjar DG, Patel HN, Patel PM. Facile Synthesis, Characterization and Properties of Triazine based Dendrimer. Int J Chem Sci. 2014, 12(2): 353-365
Svenson S, Tomalia DA. Dendrimers in Biomedical applications-reflections on the field Adv. Drug Deliv. Rev. 2012, 64: 102-115
Mignani S, Al Kazzouli SE, Bousmina M, Majoral JP. Expand classical drug administration ways by emerging routes using dendrimer drug delivery systems: A concise overview. Adv Drug Deliv Rev. 2013, 65: 1316-1330
Gajjar D, Patel R, Patel H, Patel PM. Designing of Triazine based dendrimers and its application in removal of heavy metal ions from water. Chem Sci Trans. 2014, 3: 897-908
Gajjar D, Patel R, Patel H, Patel PM. Removal of Heavy Metal Ions from Water by Hydroxyl terminated Triazine based Dendrimer. Desalin Water Treat. In Press. DOI: 10.1080/19443994.2014.922446
Grabchev I, Staneva D, Betcheva R. Fluorescent dendrimers as sensors for biologically important metal cations. Curr Med Chem. 2012, 19: 4976-4983
Twyman LJ, Ge Y. Porphyrin cored hyperbranched polymers as heme protein models. Chem Commun. 2006: 1658-1660
Steffensen MB, Hollink E, Kuschel, F, Bauer M, Simanek, EE. Dedrimers based on [1,3,5]-Triazines. J Polym Sci Part A: Polym Chem. 2006, 44: 3411-3433
Bansal KK, Kakde D, Gupta U, Jain NK. Development and Characterization of Triazine Based Dendrimers for Delivery of Antitumor Agent. J Nanosci Nanotechnol. 2010, 10: 8395-8404
Gajjar D, Patel R, Patel H, Patel PM. Designing, Characterization And Thermal Behavior Of Triazine Based Dendrimer J Poly Eng. 2015, 35: 41-52
Gajjar D, Patel R, Patel H, Patel PM. Triazine Based Dendrimer As Solubility Enhancers Of Ketoprofen: Effect Of Concentration, pH and Generation Int J Pharm Pharm Sci. 2014, 6: 357-361
Padilla De Jesús, OL, Ihre HR, Gagne L, Fréchet, JMJ, Szoka FC. Polyester dendritic systems for drug delivery applications: in vitro and in vivo evaluation. Bioconjugate Chem. 2002, 13: 453-461
Higuchi T, Connors A. Phase-solubility techniques. In: Advances in Analytical Chemistry and Instrumentation. John Wiley, New York, 1965: 117-212
Kolhe P, Misra E, Kannan RM, Kannan S, Lieh-Lai M. Drug complexation, in vitro release and cellular entry of dendrimers and hyperbranched polymers Int J Pharm. 2003, 259: 143-160
Jain S, Kaur A, Puri R, Utreja P, Jain A, Bhide M, Ratnam R, Singh V, Patil AS, Jayaraman, N, Kaushik G, Yadav S, Khanduja KL. Poly propyl ether imine (PETIM) dendrimer: A novel non-toxic dendrimer for sustained drug delivery. Eur J Med Chem. 2010, 45: 4997-5005
Lin X, Zhou J, Xu D. Facile Synthesis of Dendritic Hydroxyl-terminated Cyanuric
Chloride Derivatives and Their Properties. Chin J Chem. 2012, 30: 1485-1489
Duncan R, Izzo L. Dendrimer biocompatibility and toxicity. Adv Drug Deliv Rev. 2005, 57: 2215-2237
Domanski DM, Klajnert B, Bryszewska M. Influence of PAMAM dendrimers on human red blood cells. Bioelectrochem. 2004, 63:189-191
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