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Paraneoplastic Eosinophilia: Report of 2 Cases

Ana Revez Oliveira, Rita Isabel Calixto, Quintino Mandas Biague, Pedro Pinheirinho Costa, José Bernardino Vaz


Introduction: Eosinophilia is associated to parasitic infections, allergy, collagen-vascular and hypersensitivity diseases, while Paraneoplastic Eosinophilia is an infrequent finding associated to hematologic or solid tumors]. The physiopathological mechanism is not fully understood, despite the involvement of several growth factors.

Presentation of Case:The authors present two cases of paraneoplastic eosinophilic disease: in the first case, a 52 year-old man with history of sudden onset dyspnea, weight loss and asthenia. The chest Roëntnography showed opacity in the lower two-thirds of the right hemithorax and the blood work showed an eosinophilia of 14.300/microL (AC). The patient was admitted and performed all possible diagnostic workup, without direct signs of tumor. Despite the absence of neoplastic definitive diagnostic, the eosinophilia increased to 18.800/microL (AC), chemotherapy was considered, however after unfavorable clinical development the patient died after 31 days of hospital admission.

The other patient, a 60 year-old man with previous diagnostic and treatment of a colonic adenocarcinoma, clinically stable and without evidence of disease progression, was found evidence in a control bloodwork an eosinophilia of 4800/microL (AC). Despite discarded other causes of eosinophilia causes, was found evidence of neoplastic recurrence. The patient was eligible for chemotheraphy, the eosinophilia was oscillating during all the treatment, suspended by the 3rd cycle due to clinical deterioration. The patient died 2 weeks after treatment discontinuation.

Conclusion:Eosinophilia secondary to solid tumors is a rare finding but usually is a sign of advanced neoplastic disease or progression of a previous condition, with poor prognosis at the time of diagnostic.


Paraneoplastic; Eosinophilia; Solid Tumor; Prognosis.

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