Pure Squamous Cell Carcinoma ofthe Gall Bladder: A Rare and Aggressive Cancer

Randol Kennedy, Howard Coke, Obinna Obiekezie, Akpezi Oshobe


Introduction: Pure gall bladder squamous cell cancer comprises less than 1% of all gallbladder malignancies and prominent, well differentiated keratinization is a key histological feature.

Presentation of Case: This is a case report of an elderly male who presented with nausea and weight loss. His physical examination revealed significant hepatomegaly without jaundice. A CT scan of the abdomen revealed a large infiltrated mass in the liver with significant regional and distal enlarge lymph nodes. In comparison to a CT scan done 17 months ago - showing a normal gall bladder and liver - it was determined that this mass was likely gall bladder cancer with direct invasion into the liver. Histology via percutaneous biopsy showed pure squamous cell carcinoma, by evidence of prominent and well differentiated keratinization. He was staged as IIIb (T3N1M0) deeming the cancer unresectable with a poor prognosis.

Conclusion: Gall bladder cancer remains an uncommon cancer of a variety of histological types, in which pure squamous cell dysplasia is rare. This type of cancer is more aggressive than most other histological types and as a result is rapidly progressing, with a poor prognosis.


gall bladder cancer; squamous cell carcinoma; pure squamous cell

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