Cover Image

A Rare Presentation of Plasmablastic Lymphoma in a HIV-negative Male Status-post Liver Transplantation

Heather Katz, Natasha Bray, Naomi Montague, Barry Berman


Introduction: Plasmablastic lymphoma, a rare and aggressive form of Non-Hodgkins lymphoma, rarely presents as a retroperitoneal mass.  There are no case reports in the literature of plasmablastic lymphoma presenting in living, HIV-negative patient status post liver transplantation.

Presentation of Case: We report the case of a 63 year-old HIV-negative male status post liver transplant who presented with weakness and obstructive uropathy. Imaging showed a large mass in the retroperitonium. Biopsy revealed plasmablastic lymphoma. CHOP therapy was initiated and after six cycles, the retroperitoneal mass regressed in size; however, cytology from pleural fluid revealed that the disease remained. It has been 9 months since initial diagnosis and he was started on salvage chemotherapy with ESHAP however he subsequently developed a treatment related myelodysplastic syndrome with trisomy 12.

Conclusions: The present case is used to explore the presentation and treatment of plasmablastic lymphoma, and to review the literature concerning the rarity of this disease in the setting of a HIV-negative patient status post solid organ transplantation.


Plasmablastic lymphoma; retroperitoneal mass; transplant; HIV-negative

Full Text:



Hansra D, Montague N, Stefanovic A, et al. Oral and Extraoral Plasmablastic Lymphoma Similarities and Differences in Clinicopathologic Characteristics. American Journal of Clinical Pathology. 2010, 134: 710-719

Saraceni C, Agostino N, Cornfield D, Gupta, R. Plasmablastic lymphoma of the maxillary sinus in an HIV-negative patient: a case report and literature review. Springer Plus 2013, 2:142

Folk G, Abbondanzo S, Childers E, Foss R. Plasmablastic lymphoma: a clinicopathologic correlation. Annals of Diagnostic Pathology. 2006, 10:8-12

Teruya-Feldstein J, Chiao E, Filippa DA et al. CD 20 negative large- cell lymphoma with plasmablastic features: a clinically heterogenous spectrum in both HIV positive and negative patients. Annals of Oncology. 2004, 15:1637-1679

Colomo L, Loong F, Rives S et al. Diffuse large B cell lymphoma with plasmablastic differentiation represent a heterogeneous group of disease entities. American Journal of Surgical Pathology. 2004, 28:736-747

Castillo J, Winer E, Stachurski D, et al. HIV-negative Plasmablastic Lymphoma: Not in the Mouth. Clinical Lympoma, Myeloma, and Leukemia. 2010, 11:185-189

Vega F, Chang C, Medeiros LJ, et al. Plasmablastic lymphomas and plasmablastic plasma cell myelomas have nearly identical immunophenotypic profiles. Modern Pathology. 2005,186:806-815

Tani J, Miyoshi H, Nomura T, et al. A case of plasmablastic lymphoma of the liver without human immunodeficiency virus infection. World Journal of Gastroenterology. 2013, 37:6299 - 6303

Delecluse H, Anagnostopoulos I, Dallenbach F. Plasmblastic Lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. Blood. 1997, 89:1413-1420

Dholaria B, Alapat D, Pandey T, Agarwal A. Plasmablastic Lymphoma of the retroperitoneum in an HIV- and HCV- positive patient: hard to diagnose and harder to treat. Medical Oncology. 2012, 29:3529-3534

Takahashi Y, Saiga I, Fukushima J, et al. Plasmablastic Lymphoma of the retroperitoneum in an HIV-negative patient. Pathology International. 2009, 59:868-873

Cha J, Lee J, Joo K et al. A Case Report with Plasmablastic Lymphoma of the Jejunum. J Korean Med Sci. 2010, 25:496-500

Castillo J, Winer E, Stachurski D. et al. Prognostic factors in chemotherapy-treated patients with HIV-associated plasmablastic lymphoma. Oncologist. 2010, 15:293-299.

Van Vrancken MJ, Keglovits L, Krause J Plasmablastic lymphoma following transplantation. Proc (Bayl Univ Med Center). 2013, 26:2:152-155

National Comprehensive Cancer Network (Internet). Fort Washington (PA): NCCN Clinical Practice Guidelines in Oncology. Non-Hodgkin’s Lymphoma. 2013, Dec –(cited 2013 Dec 20) Available from:


  • There are currently no refbacks.

AJCC-REP (ISSN 2572-5742)Copyright © 2012-2021. All rights reserved. Published by Ivy Union Publishing, 3204 Valley Rush Dr, Apex, North Carolina 27502, United States