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Consecutive Tumor Lysis Syndrome and Hepatic Failure after Transarterial Chemoembolization for Treatment of Hepatocellular Aarcinoma: A Case Report and Literature Review

Shou-Wu Lee, Teng-Yu Lee, Chi-Sen Chang, Han-Chung Lien, Sheng-Shun Yang, Hong-Zen Yeh


Introduction: Acute tumor lysis syndrome (ATLS) and hepatic failure are fatal complications that can occur in patients with hepatocellular carcinoma (HCC) who undergo transarterial chemoembolization (TACE).

Presentation of Case: We report the case of a 78-year-old man with HCC who had successive ATLS and hepatic failure after the first course of TACE. He succumbed due to rapid deterioration of his condition.

Conclusion: We therefore concluded that awareness of the risks of ATLS and hepatic failure before administration of TACE is crucial in patients with HCC.


Hepatic failure; Hepatocellular carcinoma; Transarterial chemoembolization; Tumor lysis syndrome

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Hsieh PM, Hung KC, Chen YS. Tumor lysis syndrome after transarterial chemoembolization of hepatocellular carcinoma: Case reports and literature review. World J Gastroenterol. 2009, 15:4726–4728

Hsu HH, Chan YL, Chiu-Ching Huang. Acute spontaneous tumor lysis syndrome presenting with hyperuricemic acute renal failure: clinical feature therapeutic approach. J Nephrol. 2004, 7:50–56

Burney IA. Acute tumor lysis syndrome after transcatheter chemoembolization of hepatocellular carcinoma. South Med J. 1998, 91:467–470

Sharma D, Ren Z, Xia J, Ye S. Acute tumor lysis syndrome after transcatheter arterial chemoembolization in a patient with hepatocellular carcinoma. European Journal of Radiology Extra. 2006, 58:49–51

Sakamoto N, Monzawa S, Nagano H, Nishizaki H, Arai Y, Sugimura K. Acute tumor lysis syndrome caused by transcatheter oily chemoembolization in a patient with a large hepatocellular carcinoma. Cardiovasc Intervent Radiol. 2007, 30:508–511

Shiba H, Ishida Y, Wakiyama S, Sakamoto T, Misawa T, Yanaga K. Acute tumor lysis syndrome after transarterial chemoembolization for hepatocellular carcinoma. Cancer Sci. 2008, 99:2104–2105

Lee SW, Chang CS, Yeh HZ, Yang SS, Lee BJ. Recurrent hepatocellular carcinoma presenting with spontaneous acute tumor lysis syndrome: report of a case. Gastroenterol J Taiwan. 2008, 25:382–387

Huang YS, Chiang JH, Wu JC, Change FY, Lee SD. Risk of hepatic failure after transcatheter arterial chemoembolization for hepatocellular Carcinoma: Predictive value of the monoethylglycinexylidide test. Am J Gastroenterol. 2002, 97:1223–1227

Lau WY, Lai EC. Hepatocellular carcinoma: current management and recent advances. Hepatobiliary Pancreat Dis Int. 2008, 7:237–257

Baeksqaard L, Sorensen JB. Acute tumor lysis syndrome in solid tumors: a case report and review of the literature. Cancer Chemother Pharmacol. 2003, 5:87–92

Cairo MS, Bishop M. Tumour lysis syndrome: new therapeutic strategies and classification. Br J Haematol. 2004, 127:3–11

Paye F, Farges O, Dahmane M, Vilgrain V, Flejou JF, Belghiti J. Cytolysis following chemoembolization for hepatocellular carcinoma. Br J Surg. 1999, 86:176–180

Hande KR, Garrow GC. Acute tumor lysis syndrome in patients with high-grade non-Hodgkin's lymphoma. Am J Med. 993, 94:33–34

Hsin IF, Hsu CY, Huang HC, Huang YH, Lin HC, Lee RC, et al. Liver failure after transarterial chemoembolization for patients with hepatocellular carcinoma and ascites. J Clin Gastroenterol. 2011, 45:556–562

Hwang JI, Chow WK, Hung SW, Li TC, Cheng YP, Ho YJ, et al. Development of a safety index of transarterial chemoembolization for hepatocellular carcinoma to prevent acute liver damage. Anticancer Res. 2005, 25:2551–2554

Yuen MF, Chan AO, Wong BC, Hui CK, Ooi GC, Tso WK, et al. Transarterial chemoembolization for inoperable, early stage hepatocellular carcinoma in patients with Child-Pugh grade A and B: results of a comparative study in 96 Chinese patients. Am J Gastroenterol. 2003, 98:1181–1185


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