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Spontaneous Regression of Melanoma Metastases Associated with a Flare of Eczema

Shevya Manjri Tiwari, Alex Powell, Jason Dyke


Introduction: Spontaneous regression of metastatic melanoma is a rare event with only a handful of cases documented in the world literature. The phenomenonremains much of an enigma however there is an increasing body of evidence to support an immunologic basis to regression.

Presentation of case: We report a case of spontaneous regression of widespread metastatic melanoma diagnosed radiologically in a 54 year old otherwise well Caucasian woman.  Regression of metastatic disease was first noted when the patient presented with a severe flare of otherwise well controlled atopic eczema. This continued to complete regression of all metastatic disease over a period of 26 months. She remained clinically well and disease free for three years, however subsequently developed new pulmonary nodules on routine PET scan suggestive of new metastases.

Conclusion:We discuss mechanisms of regression and hypothesize that this patient’s flare of eczema was related to T cell hyperactivity induced by tumour-associated-antigens produced by melanoma cellsCases of tumour regression and research into pathways involved in regression may offer insight into novel treatment options.


Spontaneous regression; Metastatic melanoma; Immune sensitisation

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