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Leukemia Cutis and Second Primary Malignant Melanoma: An Extraordinary Case Report

Banu YAMAN, Nazan Özsan, Nisar Karadeniz, Tuğrul Dereli, Taner Akalın, Gülşen Kandiloğlu


Introduction: Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is the most common leukemia of adult. Patients with CLL/SLL are at higher risk for secondary malignancies such as skin, breast or lung tumours. Cutaneous infiltrates of CLL/SLL have been reported in association with squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and actinic keratosis.

Case Presentation: We present a patient with a previous history of CLL/SLL who developed a primary skin melanoma in the same area of leukemic infiltration, with the histological and immunohistochemical features.

An 80-year-old man presented with an 3 cm nonpigmented, erythematous and ulcerated plaque on the abdomen. Microscopically, a primary melanoma with an ulcer and skin infiltration of CLL/SLL at the ulcer base was seen.

Conclusion: Secondary cutaneous neoplasms can develop in patients with CLL/SLL and CLL/SLL infiltration can be associated with melanoma as in our case. The finding of a dense infiltrate of lymphocytes in cutaneous tumors should raise possibility of CLL/SLL and lead to a detailed examination.


Skin; Melanoma; Chronic lymphocytic leukemia/small lymphocytic lymphoma; CD20; HMB-45

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