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Intra-atrial Thrombosis Complicating Hepatocellular Carcinoma with Positive Clinical Response to Sorafenib: A Case Report and Review of Literature

Maxime Delvincourt


Introduction: Tumoral thrombus extension to inferior vena cava (IVC) and right atrium is an infrequent complication of hepatocellular carcinoma (HCC), with dismal prognosis and poorly codified treatment.

Presentation of case: We report the case of a 58-year-old man diagnosed with stage IV HCC in the right lobe of the liver, with intracavitary cardiac involvement. Under Sorafenib, the patient showed quick favourable clinical response, with decrease of the dyspnea and edema, but severe adverse effects led to early treatment discontinuation. We review the different therapeutic approaches to advanced HCC with cardiac extension.

Conclusion: Patients with intra-atrial thrombosis complicating hepatocellular carcinoma, when not eligible for surgery, might benefit from Sorafenib, to alleviate symptoms and prevent short-term cardio-vascular complications.


Hepatobiliary cancer; chemotherapy

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