Cover Image

Kimura’s Disease: A Rare Clinical Entity for A Head & Neck Surgeon

Ali Azim, Asad Azim, Talat Waseem, Kh. M. Azim


Background: Kimura’s disease, previously known as a variant of angiolymphoid hyperplasia with eiosinophilia (ALHE), is now considered a distinct clinical entity. In contrast to ALHE, it presents with exuberant systemic autoimmune response involving lymphoid system more readily and at times salivary glands. Disease typically presents with a head and neck region mass associated with peripheral eiosinophilia and raised IgE levels with occasional but concurrent renal or pulmonary involvement in advanced cases. Association of this disease to allergic rhinitis has not been reported in the previous medical literature.

Case Presentation: Young Asian male was referred to us with suspicion of primary parotid tumor. He had typical symptom complex of allergic rhinitis with recurrent frontal and parotid region swelling associated with peripheral eiosinophilia (25%) and elevated IgE levels (1703 IU/mL). FNAC of the lesions was inconclusive and hence underwent US- guided core biopsy, which revealed a diagnosis of Kimura’s disease. Superficial parotidectomy and excision of frontal lesion were performed and histopathology of the lesion confirmed Kimura’s disease with involvement of parotid gland. Now the patient is on oral corticosteroids and mast cell stabilizers without recurrence for last 3 months since operative intervention.

Conclusions: Kimura’s disease rarely involves parotid gland and its association with allergic rhinitis is being reported first time in medical literature to best of our knowledge. Kimura’s disease should include in the differential diagnosis of a parotid region mass.


Kimura’s disease; parotid gland; angiolymphoid hyperplasia with eiosinophilia; ALHE

Full Text:



Meningaud JP, Pitak-Arnnop P, Fouret P, Bertrand JC. Kimura’s's disease of the parotid region: report of 2 cases and review of the literature. J Oral MaxillofacSurg. 2007, 65:134-140

Arshad AR. Kimura’s's disease of parotid gland presenting as solitary parotid swelling. Head Neck. 2003, 25:754-757

Gao Y, Chen Y, Yu GY. Clinicopathologic study of parotid involvement in 21 cases of eosinophilic hyperplastic lymphogranuloma (Kimura’s's disease). Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006, 102:651-658

Kung IT, Gibson JB, Bannatyne PM. Kimura’s's disease: a clinico-pathological study of 21 cases and its distinction from angiolymphoid hyperplasia with eosinophilia. Pathology. 1984, 16:39-44

Chen H, Thompson LD, Aguilera NS, Abbondanzo SL. Kimura’s disease: a clinicopathologic study of 21 cases. Am J Surg Pathol. 2004, 28:505-513

Khoo BP, Chan R. Kimura’s disease: 2 case reports and a literature review. Cutis. 2002, 70:57-61

Ito S, Kume H, Kimura’s T, Yoshida N, Mizutani H, Ito Y, Suzuki R, Yamaki K. [Two cases of Kimura’s's disease associated with bronchial asthma]. Nihon Kokyuki Gakkai Zasshi. 1999, 37:1008-1012

Sah P, Kamath A, Aramanadka C, Radhakrishnan R. Kimura’s's disease - An unusual presentation involving subcutaneous tissue, parotid gland and lymph node. J Oral Maxillofac Pathol. 2013, 17:455-459

Bonfils P, Moya-Plana A, Badoual C, Nadéri S, Malinvaud D, Laccourreye O. Intraparotid Kimura’s disease. Eur Ann Otorhinolaryngol Head Neck Dis. 2013, 130:87-89

Uysal IO, Eryilmaz MA, Salk I, Abasiyanik F. Kimura’s disease in the parotid gland. J Craniofac Surg. 2011, 22:337-338

Dik VK, van de Wiel BA, Vasmel WL. Kimura’s's disease of the parotid glands and multiple cervical lymph nodes. Neth J Med. 2010, 68:175-177

Park SW, Kim HJ, Sung KJ, Lee JH, Park IS. Kimura’s disease: CT and MR imaging findings. AJNR Am J Neuroradiol. 2012, 33:784-788

Sato S, Kawashima H, Kuboshima S, Watanabe K, Kashiwagi Y, Takekuma K,Hoshika A. Combined treatment of steroids and cyclosporine in Kimura’s disease. Pediatrics. 2006, 118:e921-e923


  • There are currently no refbacks.

AJCC-REP (ISSN 2572-5742)Copyright © 2012-2021. All rights reserved. Published by Ivy Union Publishing, 3204 Valley Rush Dr, Apex, North Carolina 27502, United States