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Triple Synchronous Tumors in a Patient: Gastric Adenocarcinoma, Omental Gastrointestinal Stromal Tumor and Renal Angiomyolipoma

SEVİNÇ ŞAHİN, Selda Seçkin, Ergin Arslan, Kasım Çağlayan, Kürşad Zengin, Serhat Tanık


Introduction: The presence of synchronous distinct tumors is uncommon in the literature, and the etiology of it is still unknown.

Presentation of Case: Herein, we report a 42 year-old-woman with synchronous triple tumors of gastric adenocarcinoma, renal angiomyolipoma (AML), and omental gastrointestinal stromal tumor (GIST). She underwent total gastrectomy after the diagnosis of adenocarcinoma by endoscopic biopsy. During macroscopic examination of gastrectomy specimen, an ulcerated tumor about 4.5 cm in diameter was observed in the fundus. Histopathologically, it was diagnosed as adenocarcinoma harboring some signet-ring features. While dissecting lymph nodes of the omentum of the lesser curvature, a nodular mass about 4.2 cm in diameter seemed to be a lymph node was detected macroscopically. However, it was diagnosed as GIST by histopathological and immunohistochemical features. Also, partial nephrectomy was performed during the same session due to a mass detected radiologically in the left kidney about 2.2 cm in diameter. It was indicated to be metastatic gastric adenocarcinoma clinically but AML was determined by histopathological and immunohistochemical findings.

Conclusion: To the best of our knowledge, our patient is the first case in the literature that has synchronous tumors of gastric adenocarcinoma, omental GIST and renal AML.


Adenocarcinoma; angiomyolipoma; gastric; GIST; triple; synchronous

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