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Invasive Papillary Carcinoma of Male Breast: A Rare Case Report

Ayan Santra, Nirmalya Chakrabarti, Snehasish Das, Karabi Konar, Mala Mukherji


Introduction: Breast carcinoma in male is rare accounting less than 1% of all malignancies in men. Papillary carcinoma of breast is uncommon but carries a good prognosis. So an accurate diagnosis is essential.

Presentation of case: We report a case of this rare histological type of breast cancer in 48-year-old male patient who presented with a large mass in the right breast. Histological examination showed features of intracystic invasive papillary carcinoma.

Conclusion: The intracystic variant of papillary carcinoma is extremely unusual and may be missed on cytological examination. A thorough sampling is essential for an accurate diagnosis of invasion in these cases.


papillary carcinoma; breast; male

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Anderson WF, Devesa SS. In situ male breast carcinoma in the Surveillance, Epidemiology, and End Results database of the National Cancer Institute. Cancer. 2005, 104:1733-1741.

Sinha S, Hughes RG, Ryley NG. Papillary carcinoma in a male breast cyst: a diagnostic challenge. Ann R Coll of Surg Engl. 2006, 88(5): W3-W5

Solorzano CC, Middleton LP, Hunt KK, et al. Treatment and outcome of patients with intracystic papillary carcinoma of the breast. Am J Surg. 2002, 184(4): 364-368pp. 364-368

Salem A, Mrad K, Driss M, Hamza R, Mnif N. Intracystic papillary carcinoma of the breast. J Radiol. 2009, 90(4): 515-518

Kraus FT, Neubecker RD. The differential diagnosis of papillary tumors of the breast. Cancer. 1962, 15: 444-455

Hill CB, Yeh IT. Myoepithelial cell staining patterns of papillary breast lesions: from intraductalpapillomas to invasive papillary carcinomas. Am J ClinPathol. 2005, 123(1): 36-44

Papotti M, Eusebi V, Gugliotta P, Bussolati G. Immunohistochemical analysis of benign and malignant papillary lesions of the breast. Am J SurgPathol. 1983, 7: 451-61

Estabrook A, Asch T, Gump F, Kister SJ, Geller P. Mammographic features of intracystic papillary lesions. SurgGynecol Obstet. 1990, 170(2): 113-116

Jones BM, Bradbeer JW. The presentation and progress of macroscopic breast cysts. Br J Surg. 1980, 67(9): 669-671

Levine PH, Waisman J, Yang GCH. Aspiration cytology of cystic carcinoma of the breast. Diagnostic Cytopathol. 2003. 28(1): 39-44

Grabowski J, Salzstein SL, Sadler GR, Blair S. Intracystic papillary carcinoma: a review of 917 cases. Cancer. 2008, 113: 916-920

Fayanju OM, Ritter J, Gillanders WE, et al. Therapeutic management of intracystic papillary carcinoma of the breast: the roles of radiation and endocrine therapy. Am J Surg. 2007, 194: 497-500


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