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Leukemic Infiltration of the Esophagus, a Rare Etiology for a Common Disease

Yaseen Alastal, Tariq A Hammad, Muhammad Ali Khan, Osama Alaradi, Ali Nawras, Basmah W Khalil


Introduction: The etiology of esophagitis in patients with acute leukemia is usually related to infections, reflux, or chemotherapy toxicity. Infiltration of esophagus by leukemic cells is rarely considered in the differential diagnosis.

Presentation of Case: Here we present a case of 87-year-old male patient with a recent diagnosis of acute myelocytic leukemia who was found to have severe diffuse esophagitis secondary to leukemic infiltration.

Conclusion: Leukemic infiltration of the esophagus is a rare potential etiology of severe esophagitis in patients with disseminated leukemia. Esophageal biopsy is needed to identify the exact cause of esophageal lesions in leukemia patient.


Esophagus; leukemia

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Cornes JS, Jones TG. Leukaemic lesions of the gastrointestinal tract. J Clin Pathol. 1962, 15:305-13.

Prolla JC, Kirsner JB. The gastrointestinal lesions and complications of the leukemias. Ann Zntern Med. 1964,61:1084-103

Givler RL. Esophageal lesions in leukemia and lymphoma. Am J Dig Dis. 1970. Jan;15(1):31-36

Fulp SR, Nestok BR, Powell BL, Evans JK, Geisinger KR, Gilliam JH 3rd. Leukemic infiltration of the esophagus. Cancer. 1993, 71(1):112-116

Slee GR, Wagner SM, McCullough FS. Odynophagia in patients with malignant disorders. Cancer. 1985, 55(12):2877-2879

Thompson BC, Feczko PJ, Mezwa DG. Dysphagia caused by acute leukemic infiltration of the esophagus. AJR Am J Roentgenol. 1990, 155(3):654

Isomoto H, Ohnita K, Mizuta Y, Maeda T, Omagari K, Miyazaki M, Murase K, Hasui K, Murata I, Kohno S. Adult T-cell leukemia with an unusual esophageal lesion. Gastrointest Endosc. 2001, 53(6):673-675

Dixit MP, Farias KB, McQuade M, Scott KM. Acute myelo-monocytic infiltrate of the lower esophagus in a 4-year-old renal transplant recipient. Am J Kidney Dis. 2003, 41(5):E16

Konstantinidis N, Kolarovic J, Vukavic T, Kacanski N, Vuckovic N. Esophageal leukemic infiltration in children. J Pediatr Gastroenterol Nutr. 2011, 52(6):781-783


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