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Metastatic Clear Cell Hidradenocarcinoma: Response to Chemotherapy and Long Disease Control

Mouna Ayadi, Feryel Letaief ksontini, Khadija Meddeb, Amina Mokrani, Yosra Yahyaoui, Nesrine Chrait, Henda Rais H, Khadija Bellil, Amel Mezlini


Introduction: Hidradenocarcinoma is a rare aggressive tumor arising from sweat glands that may occur from preexisting hidradenoma or most frequently appears de novo. It is often located in the head and neck. It is also characterized by a high potential of local recurrence, metastasis and poor outcome. This tumor is often radiotherapy and chemotherapy resistant.

Presentation of case: We report a case of a 77-year-old man with a metastatic hidradenocarcinoma to the bone and lymph nodes who was operated 7 years ago for an hidradenoma of the right foot. He was treated with capecitabine-based chemotherapy with good tolerance and obtention of partial response during 10 months. After that, his disease progressed and he died 1 year after diagnosis.

Conclusion: Hidradenocarcinoma is a cancer with a poor prognosis . Because of its low prevalence and high rate of recurrence, its treatment is still controversial. Our good result demonstrates that adjunction of chemotherapy in metastatic forms is effective for a better control and long overall survival.


Metastatic Hidradenocarcinoma; chemotherapy; capecitabine; disease control

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