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Spontaneous Regression of Malignant Melanoma of the Gastro-Oesophageal Junction

Steven Thomas Hornby, Peter Alexander Newman, Usman Hassan, William Bryson Robb


Introduction: Both esophageal melanoma and regression of malignant melanoma are rare occurrences and exist in the literature mainly in the form of case reports. There have been no reported cases of complete regression of primary malignant melanoma of the esophagus.

Presentation of the Case: A 57 family doctor was found on routine blood tests to have an iron deficiency anaemia. Upper gastrointestinal endoscopy revealed a tumor of the gastroesophageal junction (GEJ) and biopsies confirmed a malignant melanoma. Staging investigations were performed and the patient proceeded to have a primary open Ivor-Lewis esophagetomy. Histopathological examination of the resected specimen showed no active tumor.

Conclusion: Regression of melanoma is a rare occurrence and may be related to the immunogenic nature of the cancer. It has been associated both favourably and negatively in the literature with prognosis. There are no reported cases of complete regression of disease where the primary tumor has been in the esophagus.


Oesophageal Melanoma; Melanoma Regression

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