Breast Metastasis from Differentiated Thyroid Carcinoma Primary: A Case Report and Review of Literature
Abstract
Introduction: Metastasis to the breast from non-mammary malignancy is rare, with a reported incidence of less than 1%[2-4]. Aside from hematologic malignancies and contralateral breast cancer, the most common primary malignancies that metastasize to the breast are lung, ovarian, gastrointestinal cancers, and melanoma.
Presentation of Case: We present an 82-year-old female with metastatic breast cancer arising from a primary papillary thyroid carcinoma. She presented with a palpable right breast mass 4 years after resection and treatment of a primary thyroid cancer.
Conclusion: Ultrasound guided core biopsy and immunohistochemical staining demonstrated metastatic papillary thyroid carcinoma. The patient underwent lymphoscintigraphy and subsequent resection of the breast mass along with two axillary lymph nodes.
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SEER Cancer Statistics Factsheets: Breast Cancer. National Cancer Institute. Bethesda, MD,http://seer.cancer.gov/statfacts/html/breast.html
DeLair DF, Corben AD, Catalano JP, Vallejo CE, Brogi E, and Tan LK. Non-mammary metastases to the breast and axilla: a study of 85 cases. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc, 2013, 26, 343-9. doi:10.1038/modpathol.2012.191
Maounis N, Chorti M, Legaki S, Ellina E, Emmanouilidou A, Demonakou M, and Tsiafaki X. Metastasis to the breast from an adenocarcinoma of the lung with extensive micropapillary component: a case report and review of the literature. Diagnostic pathology. 2010, 82 . doi:10.1186/1746-1596-5-82
Toombs BD, and Kalisher L. Metastatic disease to the breast: clinical, pathologic, and radiographic features. American Journal of Roentgenology. 1977, 129:673-676
Cangiarella J. Metastases to the Breast. In Breast cytohistology (1st ed., Vol. 1, pp. 195-202). Cambridge: Cambridge University Press, 2013
Williams SA, Ehlers RA, Hunt KK, Yi M, Kuerer HM, Singletary SE, et al. Metastases to the breast from nonbreast solid neoplasms: Presentation and determinants of survival. Cancer. 2007, 110:731-737
Mazzaferri EL, Jhiang SM. Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. The American Journal of Medicine, 1994, 97:418
Eustatia-Rutten CFA, Corssmit EPM, Biermasz NR, Pereira AM, Romijn JA, and Smit JW. Survival and death causes in differentiated thyroid carcinoma. Journal of Clinical Endocrinology and Metabolism. 2006, 91, 313-319
LiVolsi VA. Papillary thyroid carcinoma: an update. Mod Pathol. 2011, 24:S1-S9
Song HJ, Xue YL, Qiu ZL, and Luo QY. Uncommon metastases from differentiated thyroid carcinoma. Hellenic Journal of Nuclear Medicine. 2012, doi:10.1967/s002449910059
Corrado G, Pomati G, Russo A, Visca P, Vincenzoni C, Patriz, L, and Vizza E. Ovarian Metastasis from Thyroid Carcinoma: A Case Report and Literature Review. Diagnostic Pathology. 2014, 9(1):193-193
Tuttle RM. Risk-adapted management of thyroid cancer. Endocrine Practice. 2008,14:764-774
Luster M, Weber T, and Verburg FA. Differentiated thyroid cancer-personalized therapies to prevent overtreatment. Nature Reviews Endocrinology. 2014, 10(9):563-574
Ota T. Papillary Carcinoma of the Thyroid with Distant Metastases to the Cerebrum: a Case Report. Japanese Journal of Clinical Oncology. 2001, 31, 112-115
Zhou S, Yu B, Cheng Y, Xu X, Shui R, Bi R, et al. Metastasis to the breast from non-mammary malignancies: A clinicopathologic study of 28 cases. Chinese Journal of Pathology. 2014, 43(4):231-235
The American Cancer Society. Diagnostic tests for breast conditions. (2014, July 21). Retrieved from: http://www.cancer.org/treatment/understandingyourdiagnosis/examsandtestdescriptions/forwomenfacingabreastbiopsy/breast-biopsy-diagnostic-tests-used
Dabbs, D. Immunohistochemistry of Metastatic Carcinoma of Unknown Primary Site. In Diagnostic immunohistochemistry: Theranostic and genomic applications (Fourth ed., pp. 204-38). Philadelphia: Saunders. 2013
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