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Therapy Related Chronic Myeloid Leukemia (trCML) or non-Therapy Related Second Malignancy Chronic Myeloid Leukemia (smCML) following Diffuse Large B-Cell Lymphoma(DLBCL): A Case Report and Review of Literature

Robert Louis, Sunil Kumar Gupta, Sonal Jain, Anurag Mehta, Mohit Agarwal




Introduction: Second malignancy could be either previous therapy related or non-therapy related like syndromic or shared etiologic exposure. It could be either a hematological/solid malignancy following tretment for previous solid tumour or prior hematological malignanacy.Review of literature regarding secondary Chronic Myeloid Leukemia (CML) following previous active treatment for primary cancer is listed out for further understanding.

Presentation of Case: We describe a 71 year old elderly male who developed Chronic Myeloid Leukemia(CML) after a period of 6 years during follow up of Stage IV Diffuse Large B-Cell Lymphoma(DLBCL) for which he received 8 cycles of R-CHOP based Chemo-immunotherapy in 2008 .Whether it is therapy related Chronic Myeloid Leukemia (trCML) following prior cytotoxic treatment or simply a non-therapy related second malignancy hronic Myeloid Leukemia(smCML) is a matter of debate.However our patient responded dramatically like denova CML to imatinib therapy.

Conclusion: Therapy related CML or non therapy related second malignancy CML following DLBCL treatment is rare but responds dramatically like denova CML to imatinib therapy.








Therapy-related CML; Second malignancy CML; CML following DLBCL treatment

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