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Renal Failure due to Direct Infiltration of Chronic Lymphocytic Leukemia: Case report and Review of Treatment

Bartlomiej Posnik, Nina Undevia Yedavalli


Background: Chronic lymphocytic leukemia (CLL) is a cancer due to the uncontrolled growth and accumulation of mature B lymphocytes in the bone marrow and blood. Asymptomatic kidney involvement of CLL is fairly common but renal failure secondary to CLL is very rare.

Case Presentation: Less than twenty cases of acute renal failure due to the direct CLL infiltration have been reported in the literature. Given the rarity of this complication, there is no standard of care on how these patients’ treatment should be approached. We present a case of renal failure in a patient with a longstanding history of CLL.

Conclusion:In order to guide future management, our discussion features a detailed review of the literature with a focus on the various treatment modalities used in this very rare complication.


Chronic lymphocytic leukemia; renal failure; renal biopsy; treatment

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