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Segment MP of Influenza A Virus Contains a Novel Gene in Positive-sense Orientation

Vivek Darapaneni


Influenza A Virus with its global dominance is a significant pathogen. Influenza A Virus is responsible for seasonal epidemics, apart from the pandemics which occur occasionally.  Investigation of influenza A virus genomes from various strains of influenza A virus belonging to various hosts, revealed a novel open reading frame encoding a protein of 126 residues long with a molecular weight of ~13.9kDa in a (+) sense orientation. This protein is named as NEG7 and is a single pass transmembrane protein with a putative ion channel function. Identification of this novel (+) sense oriented ORF, further confirms the concept of ambisense (bipolar) functioning of the influenza A virus genome.



Ion channel; Open reading frame; Transmembrane; Ambisense; Positive-sense; Orientation

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