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Assessment of Invitro Anticancer Potential of Marine Derived Fungus Collected from South West Coast of Tamilnadu

Ponpandian Samuel, D.N.P. Sudarmani

Abstract


Cancer is currently one of the most globally prevalent diseases. Furthermore, the incidence of cancer is steadily increasing, accompanying the ageing and growth of populations, as well as imbalanced life-styles and declining environmental conditions. The present work describes the anticancer activity of marine sediment derived fungus obtained during the course of sampling. The marine sediments were collected from the south west coastal area of Tamilnadu. Sampling results in the isolation of 58 fungi belongs to 37 genera. Among the 58 fungal isolates, the frequent fungus Aspergillus flavus was isolated from the sediment based on frequency of distribution, while it was cultured on Potato Dextrose Agar (PDA) amended with streptomycin 150 units/ml. The second half of the study was based on the production of secondary metabolites on different fermentation medium. The metabolites were concentrated using rotary vacuum evaporator. The anticancer activity of the metabolites was evaluated on HeLa cell lines purchased from National centre for cell sciences, Pune. Further the result revealed that the metabolite produced by the isolated fungus has showed positive cell inhibitory effect on cell lines. The determined IC50 value of the metabolite was 29.03 µg/ml. The study concludes that the marine derived organisms especially fungus is a promising target to be exploited against the hunt for cancer.

Keywords


marine sediment; Aspergillus flavus; Human breast adenocarcinoma cell line; IC50

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