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Overview of Diverse Pharmacological Activities of Substituted Coumarins: Compounds with Therapeutic Potentials

Mohammad Asif

Abstract


Coumarins are well known plant derived natural product which is extensively used as a biological active compound. Coumarins have attracted considerable attention of medicinal chemists and pharmacologists and have been demonstrated to bear many pharmacological activities. Natural and synthetic coumarins were verified to have antioxidant, antiinflammatory, anticoagulation, estrogenic, dermal photosensitizing, vasodilator, molluscicidal, anti helmentic, sedative, hypnotic, analgesic, hypothermic, antimicrobial, anticancer, anticonvulsant, antihyperlipidemic, tyrosinase inhibitor and anti-parkinsonism and antiulcer activities. This review is based on recent studies of coumarins and coumarin related compounds. Therefore the focus will be on their pharmacological importance along with the various synthesis methods. The aim of the paper is to review the available information on substituted coumarins.

Keywords


Pharmacological activities; synthesis, benzopyrone; antioxidant; anti-inflammatory; antimicrobial; anticancer; anticonvulsant; anticoagulant; substituted coumarins

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