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Biological Potential of Substituted Thiadiazole Compounds

Mohammad Asif


Heterocyclic compounds are present in most biologically active molecules. The chemistry of heterocyclic compounds has been an interesting field of study. Heterocyclic nucleus 1,3,4-thiadiazole constitutes constitutes an important class of compounds for drug development. The novel thiadiazoles and investigation of their chemical and biological behavior have gained more importance in recent decades. There has been intense investigation of different classes of thiadiazole compounds, many of which possess extensive pharmacological activities. The 1,3,4-thiadiazole nucleus is one of the most important and well-known heterocyclic nuclei, which is a common and integral feature of a variety of natural products and medicinal agents. Thiadiazole nucleus is present as a core structural component in an array of drug categories. The broad and potent activity of thiadiazole and their derivatives has established them as pharmacologically significant scaffolds. 1,3,4-Thiadiazole nucleus exhibited remarkable pharmacological activities Such as antibacterial, antifungal, antitubercular, antiviral, antileishmanial, anti-inflammatory, analgesic, antidepressant, anticonvulsant, anticancer, antioxidant, antidiabetic, molluscicidal, antihypertensive, diuretic.  So far, modifications of the thiadiazole ring have proven highly effective with improved potency and lesser toxicity. The present review highlights the recently synthesized thiadiazole possessing important biological activities.


1,3,4-thiadiazole; antimicrobial activity; biological activities

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