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Anticonvulsant Activities of Various Series of Heterocyclic Compounds Containing Triazole, Thiadiazine, Benzo-triazole, Benzothiazole, Oxadiazole Ring Systems

Mohammad Asif

Abstract


In searching for better anticonvulsant drug and the importance of 2,5-disubstituted 1,3,4-oxadiazoles, 2-amino-5- {2-[(2,6-dichlorophenyl)amino]benzyl}-1,3,4-oxadiazole (1), 1-(5-{2-[(2,6-dichlorophenyl)amino]benzyl}-1,3,4- oxadiazol-2-yl)-urea (2) and N-(5-{2-[(2,6-dichlorophenyl) amino]benzyl}-1,3,4-oxadiazol-2-yl)-hydrazine carbox-amide (3) and  N1-(5-{2-[(2,6-dichlorophenyl)amino]benzyl}-1,3,4-oxadiazol-2-yl)-N4-(4-substituted benzaldehyde) -semicarbazones (4a-f) and N1-(5-{2-[(2,6-dichloro phenyl) amino] benzyl}-1,3,4-oxadiazol-2-yl)-N4-[1-(4-substituted phenyl) ethanone]-semicarbazone (5a-d) and N1-(5-{2-[(2,6-dichlorophenyl) amino]benzyl}-1,3,4-oxadiazol-2-yl) -N4-[1-(4-substituted henyl) (phenyl) methanone]-semicarbazones (6a-d) were evaluated for their anticonvulsant activity. Among all the compounds, 6b emerged out as the most potent compound. The anticonvulsant activity of 7-alkoxy- triazolo-[3,4-b]benzo[d]thiazoles (7a-u). Most compounds showed good anticonvulsant activity. Compound (7g) was found to be the most potent compound. A series of 2-(1H-Benzotriazol-1-yl)-N'-[substituted]acetohydrazides (8a-j) were tested for anticonvulsant activity and the most active compound was (8i). Various 6-phenyl-7H-[1,2,4]triazolo [3,4-b] [1,3,4] thiadiazines (9a-n) fused with 1,2,4-triazoles. Most compounds showed some degree of anticonvulsant activity. Compound (9h) was the most promising compound. A series of benzothiazole sulfonamides, 2-Amino-1,3-benzothiazoles (10a-c), 6-Sulfamido-1,3-benzothiazo-2-yl-thiosemicarbazides (11a-c) and N-[(1,3-benzothiazole-2-ylamino) (imino)methyl]-nitro-benzene sulfonamides 12a-b  were tested for the anticonvulsant activity. The significant results were found with compounds (11c) and (10c). Compound (10c), (11c) and compound (10b) were found to be raised in the onset of convulsion and other test drugs showed moderate protection.


Keywords


Anticonvulsant; triazole; thiadiazine; Benzotriazole; benzothiazole; oxadiazoles

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References


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