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Synthesis and Characterization of Novel Oxoazetidine containing Phenyl Imidazole Carbamates

Esther Rani


The pharmacological important of nitrogen containing heterocyclic of novel Oxoazetidine containing Phenyl Imidazole Carbamates 8(a-d) which are synthesize from reaction between aldehyde, aniline and monochloro acetyl chloride via Schiff base intermediate which on under goes with reaction of acid, azide and alcohols. The Oxoazetidines were established by IR, 1H NMR, 13CNMR and mass spectral analysis.


Imidazole; Oxoazetidine and Schiff base

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Koppel GA. In small ring Heterocycles, part 2, ed, A. Hassner, Wiley-Interscience, Newyork, 1983, p.219

Delpiccolo CML, Fraga MA, Mata EG. An Efficient, Stereoselective Solid-Phase Synthesis of _β-lactams Using Mukaiyama’s Salt for the Staudinger Reaction. J Comb Chem. 2003, 5:208-210

Patel RB, Desai PS, Desai KR, Chikhalia KH. Synthesis of pyrimidine based thiazolidinones and azetidinones: antimicrobial and antitubercular agents. Indian J Chem. 2006, 45B:773-778

Siddiqui N, Rana A, Khan SA, Haque SE, Alam MS, Ahsan W, Arshada MF. Anticonvulsant and Toxicity Evaluation of Newly Synthesized 1-2-(3,4-disubstitutedphenyl)-3-chloro-4-oxoazetidin-1-yl-3-(6-substituted-1,3-benzothiazol-2-yl)ureas. Acta Chim. Slov. 2009, 56:462-469

Srivastava SK, Dua R, Srivastava SD. Synthesis and antimicrobial activity of [N1-(N-substitutedarylidene- hydrazino)-acetyl]-2-methyl-imidazoles and [N1-(4-substituted aryl-3-chloro-2-oxo-1- azetidinyl-amino)-acetyl]-2-methyl-imidazoles. Proc Nat Acad Sci India, Sec. A: Phys. Sci. 2010, 80:117-121

Trivedi PB, Undavia NK, Dave AM, Bhatt KN, Desai NC. Synthesis and antimicrobial activity of 4-oxothiazolidines, 4-oxoazetidines, malonanilic acid hydrazines and pyrazoline derivatives of phenothiazine. Indian J Chem. 1993, 32B (7):760-765

Panwar H, Verma RS, Srivastava VK, Kumar A. Synthesis of some substituted Azetidinonyl and thiazolidinonyl-1,3,4-thiadiazino[6,5-b]indoles as prospective antimicrobial agents. Indian J Chem. 2006, 45B:2099-2104

Srivastava, S.K.; Srivastava, S.L.; Srivastava, S.D. Synthesis of new 2-chloro phenothiadiazol-2-oxoazetidines antimicrobial and anti-inflammatory agents. Indian J Chem. 2000, 39B:464-467

Kumar A, Gurtu S, Agarwal JC, Sinha JN, Bhargava KP, Shanker K. Synthesis and cardiovascular activity of substituted 4-azetidinones. J Indian Chem Soc. 1983, 60(6):608-610


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