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Fascin-1 and Digestive System Carcinoma

Liang Zhou, Zhao-xu Yang, Qing-jun Li, Wei Sun, Yong Zhang, De-sheng Wang, Ke-feng Dou

Abstract


Invasion and metastasis are major reason for poor prognosis of digestive system carcinoma patients. Motility and migratory capacity are important in contributing to tumor cells’ invasion and metastasis. Fascin is one of actin cross-linking proteins and can participate in forming parallel actin bundles in cell protrusions. Fascin-1 is consequently involved in cell adhesion, motility, and signaling. In cultured cells, over-expression of fascin-1 can increase migration and invasion capacity of cells. Many studies show up-expressions of fascin-1 are significantly associated with worse prognosis, poor differentiation, TNM stage, positive for lymph node metastasis, and positive for distant metastasis in digestive system carcinoma patients. So fascin-1 may have prognostic value as an early biomarker for more aggressive digestive system carcinoma. This review provides detailed account of preclinical studies conducted to determine the utility of fascin-1 as a therapeutic and predictive agent in invasion and metastasis of carcinomas.

Keywords


Fascin; Invasion; Metastasis; Carcinoma; Digestive System

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References


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