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Antioxidant Networks In vivo

Dorota Bartusik, David Aebisher, Ewa Bartosińska, Danuta Siluk, Boguslaw Tomanek

Abstract


Oxygen interacts with cells and can form highly reactive compounds in vivo known as reactive oxygen species (ROS). High levels of ROS can lead to cellular damage, oxidative stress, heart diseases and cancer. Known substances that are capable of halting the physiological process of oxidation in tissue are called antioxidants.

This review covers developments in the field of antioxidant chemistry including interactions between antioxidants and ROS, topics about sources and natural occurrences, classification of antioxidants and a discussion of possible mechanisms. We also summarize examples of oxidative stress biomarkers.


 


Keywords


antioxidants; cancer

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References


Halliwell B. Antioxidants: the basics – what they are and how to evaluate them. Adv Pharmacol. 1997, 38:3-20

Bajaj S, Khan A. Antioxidants and diabetes. Int J Endocrinol Metab. 2012, 16:267-271

Southorn PA, Powis G. Free radicals in medicine. I. Chemical nature and biologic reactions. Mayo Clin Proc. 1988, 63:381-389

Maritim AC, Sanders RA, Watkins JB 3rd. Review Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxic. 2003, 17:24-38

Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matsumura T, Kaneda Y, Yorek MA, Beebe D, Oates PJ, Hammes HP, Giardino I, Brownlee M. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature. 2000, 404:787-790

Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001, 414:813-820

Boullier A, Bird DA, Chang MK, Dennis EA, Friedman P, Gillotre-Taylor K, Hörkkö S, Palinski W, Quehenberger O, Shaw P, Steinberg D, Terpstra V, Witztum JL. Scavenger receptors, oxidized LDL, and atherosclerosis. Ann NY Acad Sci.2001, 947:214-222

Chatgilialoglu C, Ferreri C, Masi A, Melchiorre M, Sansone A, Terzidis MA, Torreggiani A. Free radicals in chemical biology: from chemical behavior to biomarker development. J Vis Exp. 2013, e5037

Lonn EM, Yusuf S. Is there a role for antioxidant vitamins in the prevention of cardiovascular diseases? An update on epidemiological and clinical trials data. Can J Cardio.1997, 13:957-965

Anker SD, Doehner W, Rauchhaus M, Sharma R, Francis D, Knosalla C, Davos CH, Cicoira M, Shamim W, Kemp M, Uric acid and survival in chronic heart failure: validation and pplication in metabolic, functional, and hemodynamic staging. Circulation. 2003, 107:1991-1997

Jacob S, Ruus P, Hermann R, Tritschler HJ, Maerker E, Renn W, Augustin HJ, Dietze GJ, Rett K. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients withtype-2 diabetes mellitus: A placebo-controlled pilot trial. Free Radic Biol Med. 1999, 27:309-314.

Halliwell, B. Free Radicals, Antioxidants, and Human Disease: Curiosity, Cause, or Consequence? Lancet. 1994, 344:721-724

Kadiiska M B, Gladen BC, Baird DD, Germolec D, Graham LB, Parker CE, Nyska A, Wachsman JT, Ames BN, Basu S, Brot N, Fitzgerald GA, Floyd RA., George M, Heinecke J. W, Hatch GE, Hensley K, Lawson JA., Marnett LJ, Morrow JD, Murray DM, Plastaras J, Roberts L J, Rocach J, Shigenaga MK, Sohal RS, Sun J, Tice RR, Van Thiel DH, Wellner D, Walter PB, Tomer KB., Mason RP., and Barrett JC. Biomarkers of Oxidative Stress Study. II. Are Oxidation Products of Lipids, Proteins and DNA Markers in CCl4 Poisoning? Free Radic Biol Med. 2005, 38:698-710

Maoodi M, Mir AA, Petasis NA, Serhan CN, Nicolaou A. Simultaneous lipidomic analysis of three families of bioactive lipid mediators leukotrienes, resolvins, protectins and related hydroxyl-fatty acids by liquid chromatography/electrospray tandem mass spectrometry. Rapid Commun Mass Spectrom. 2008, 22:75-83

Hawkins CL, Morgan PE, Davies MJ. Quantification of protein modification by oxidants. Free Radic Bio Med. 2009, 46:965-988

Desco MC, Asensi M, Márquez R, Martínez-Valls J, Vento M, Pallardó FV, Sastre J, Viña, J. Xanthine oxidase is involved in free radical production in type 1 diabetes: Protection by allopurinol. Diabetes. 2002, 51:1118-1124

Pietta PG. Flavonoids as antioxidants. J Nat Prod. 2000, 63:1035-1042

Milner JA. Reducing the Risk of Cancer. In: Goldberg I ed., Functional Foods. New York: Chapman and Hall. 1994:39-70

Rizzo AM, Berselli P, Zava S, Montorfano G, Negroni M, Corsetto P, Berra B. Endogenous antioxidants and radical scavengers. Adv Exp Med Biol. 2010, 698:52-67

Peng C, Wang X, Chen J, Jiao R, Wang L, Li YM, Zuo Y, Liu Y, Lei L, Ma KY, Huang Y, Chen ZY. Biology of ageing and role of dietary antioxidants. Biomed Res Int. 2014, 2014:83184

Levy MA, Tsai YH, Reaume A, Bray TM. Cellular response of antioxidant metalloproteins in Cu/Zn SOD transgenic mice exposed to hyperoxia. Am J Physiol Lung Cell Mol Physiol. 2001, 281:L172-182

Sitar ME, Aydin S, Cakatay U. Human serum albumin and its relation with oxidative stress. Clin Lab. 2013, 59:945-952

Elshafie MM, Nawar IA, Algamal MA, Ahmad SA. Evaluation of the Biological Effects for Adding Cinnamon Volatile Oil and TBHQ as Antioxidant on Rats’ Lipid Profiles. Asian J Plant Sci. 2012, 11:100-108

Bland JS. Oxidants and Antioxidants in Clinical Medicine: Past, Present, and Future Potential. J Nutr Environ Med. 1995, 5:255-280

Golumbic C, Mattill H A. Antioxidants and autoxidation of fats. XIII. The antioxygenic action of ascorbic acid in association with tocopherols, hydroquinones and related compounds. J Am Chem Soc. 1941, 63:1279-1280

Tappel, A. L. Will antioxidant nutrients slow aging processes? Geriatrics 1968, 23:99-105

Niki E, Noguchi N. Dynamics of antioxidant action of vitamin E. Acc Chem Res. 2004, 37:45-51

Barclay LRC, Baskin KA, Dakin KA, Locke SJ, Vinquist MR. The antioxidant activity of phenolic antioxidants in free radical peroxidation of phospholipids membranes. Can J Chem. 1990, 68:2258-2269

Firuzi O, Miri R, Tavakkoli M, Saso L. Antioxidant therapy: current status and future prospects. Current Medicinal Chemistry. 2011, 18:3871-3888

Hennekens CH, Gaziano JM., Antioxidants and Heart Disease: Epidemiology and Clinical Evidence. Clin Cardiol. 1993, 16(suppl I):I-10, I-15

Stone WL, Krishnan K, Campbell SE, Palau VE, The role of antioxidants and pro-oxidants in colon cancer. World J Gastrointest Oncol. 2014, 6:55-66

Block G. Fruit, Vegetables, and Cancer Prevention: A Review of the Epidemiological Evidence, Nutr Cancer. 1992, 18:1-29

Leenders M, Leufkens AM, Siersema PD, van Duijnhoven FJ, Vrieling A, Hulshof PJ, van Gils CH, Overvad K, Roswall N, Kyrø C, Boutron-Ruault MC, Fagerhazzi G, Cadeau C, Kühn T, Johnson T, Boeing H, Aleksandrova K, Trichopoulou A, Klinaki E, Androulidaki A, Palli D, Grioni S, Sacerdote C, Tumino R, Panico S, Bakker MF, Skeie G, Weiderpass E, Jakszyn P, Barricarte A, Huerta JM, Molina-Montes E, Argüelles M, Johansson I, Ljuslinder I, Key TJ, Bradbury KE, Khaw KT, Wareham NJ, Ferrari P, Duarte-Salles T, Jenab M, Gunter MJ, Vergnaud AC, Wark PA, Bueno-de-Mesquita HB.Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the european prospective investigation into cancer and nutrition. Int J Cancer. 2014, 135:2930-2939

Glantzounis GK, TsimoyiannisEC,Kappas AM, Galaris DA. Uric Acid and Oxidative Stress.Curr Pharm Des. 2005, 11:4145-4151

Khaw K-T; Woodhouse P. Interrelation of vitamin C, infection, haemostatic factors, and cardiovascular disease. BMJ. 1995, 310:1559-1563

Morrison JA, Jacobsen DW, Sprecher DL, Robinson K, Khoury P, Daniels SR. Serum glutathione in adolescent males predicts parental coronary heart disease. Circulation. 1999, 100:2244-2247

Teichert J, Preiss R. HPLC-methods for determination of lipoic acid and its reduced form in human plasma. International Journal of Clinical Pharmacology, Therapy, and Toxicology. 1992, 30:511-512

ČEstmír Z, Overvad K, Mortensen SA, Sindberg CD, Moesgaard S, Hunter DA. Serum coenzyme Q10concentrations in healthy men supplemented with 30 mg or 100 mg coenzyme Q10 for two months in a randomised controlled study. Bio Factors. 2003, 18:185-193

Godic A, Poljšak B, Adamic M, Dahmane R. The Role of Antioxidants in Skin Cancer Prevention and Treatment. Oxid Med Cell Longev. 2014, 2014:860479

da Silva SB, Costa JP, Pintado ME, Ferreira DC, Sarmento B. Antioxidants in the prevention and treatment of diabetic retinopathy - a review. J Diab Metab. 2010, 1:111-118

Golbidi S, Badran M, Laher I. Antioxidant and anti-inflammatory effects of exercise in diabetic patients. Exp Diab Res. 2012, 2012:941868

Rolo AP, Palmeira CM. Diabetes and mitochondrialfunction: Role of hyperglycemia and oxidative stress. Toxic App Pharm. 2006, 212:167-178

Steinhubl SR. Why have antioxidants failed in clinical trials? American Journal of Cardiology. 2008, 101:14D-19D

Ruhe RC, McDonald RB. Use of antioxidant nutrients in the prevention and treatment of type 2 diabetes. J Am CollNutr. 2001, 20:363-369

El-Sohemy A, Baylin A, Kabagambe E, Ascherio A, Spiegelman D, Campos H. Individual carotenoid concentrations in adipose tissue and plasma as biomarkers of dietary intake. Am J ClinNutr. 2002, 76:172-179

SiesH,Stahl W. Vitamins E and C, beta carotene, and other carotenoids as antioxidants. Am J ClinNutr 1995;62(suppl):1315S-21S

Fontham ET. Vitamin C, Vitamin C-Rich Foods, and Cancer: Epidemiologic Studies. San Diego: Academic Press.1994

Hamilton SJ, Chew GT, Watts GF. Therapeutic regulation of endothelial dysfunction in type 2 diabetes mellitus.Diab Vas Dis Res. 2007, 4:89-102

Jacob RA. The integrated antioxidant system. Nutr Res. 1995, 15:755-766

Blot WJ, Li JY, Taylor PR,Guo W, Dawsey S, Wang GQ, Yang CS, Zheng SF, Gail M, Li GY, Yu Y, Liu B, Tangrea J, Sun Y, Liu F, Fraumeni JF, Zhang Jr, YH, LiB. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Nat Cancer Inst 1993, 85:1483-1491

Omenn GS, Goodman G, Thomquist M, Grizzle J, Rosenstock L, Barnhart S, Balmes J, Cherniack MG, Cullen MR, Glass A, Keogh J, Meyskens F Jr, Valanis B, Williams J Jr, The beta-carotene and retinol efficacy trial (CARET) for chemoprevention of lung cancer in high risk populations: smokers and asbestos-exposed workers. Cancer Res. 1994, 54:2038-2043

Lee, IM; Cook, NR; Manson, JE. Beta-carotene supplementation and incidence of cancer and cardiovascular disease: Women’s Health Study. J Nat Cancer Inst. 1999, 91:2102-2106

Sowell AL, Huff DL, Yeager PR, Caudill SP, Gunter EW. Retinol, alpha-tocopherol, lutein/zeaxanthin, beta-cryptoxanthin, lycopene, alpha-carotene, trans-beta-carotene, and four retinyl esters in serum determined simultaneously by reversed-phase HPLC with multiwavelength detection. Clin Chem. 1994, 40:411-416

Golumbic C, Mattill HA. Antioxidants and autoxidation of fats. XIII. Theantioxygenic action of ascorbic acid in association with tocopherols, hydroquinonesand related compounds. J Am Chem Soc. 1941, 63:1279-1280

Tappel AL. Will antioxidant nutrients slow aging processes? Geriatrics. 1968, 23:99-105

Firuzi O, Miri R, Tavakkoli M, Saso L. Antioxidant therapy: current status and future prospects. Curr Med Chem. 2011, 18:3871-3888

Hennekens CH, Buring JE, Manson JE, Stampfer M, Rosner B, Cook NR, Belanger C, LaMotte F, Gaziano JM, Ridker PM, Willett W, Peto R. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. New Eng J Med. 1996, 334:1145-1149


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