Altered Platelets Morphological Parameters in Obese Adults with Type 2 Diabetes Mellitus in Sudan

Magdi Bayoumi, Sheraz Mourtadaa, Sahar Elbager

Abstract


Background: Obesity and diabetes are growing global health problems that significantly affect patient quality of life and associated with an increased risk factor for cardiovascular diseases. Accumulating evidence indicates that platelet hyperactivity is a contributing factor to the cardiovascular complications. This study aimed to evaluate the platelet morphological parameters and platelets count in obese type 2 diabetes mellitus in adult patients.

Method: A total of 190 subjects, 90 types 2 diabetes mellitus patients without known cardiovascular diseases [60 obese with BMI ≥30 kg/m2 and 30 non-obese] and 100 age and the sex-matched non-diabetic control group included from adults undergoing routine investigation for other problems in the same center. Venous blood samples were collected in EDTA. Platelet counts and Platelet morphological parameters [MPV, PDW] were performed using the Sysmex KN-21N.

Results: The mean platelet counts in the diabetic group were higher than in the non-diabetic group, but the difference was not statistically significant (275.7±70 vs. 261.9±59 × 10 9 /L; P > 0.05). The mean MPV was significantly higher in type 2 diabetic group as compared with the non-diabetic group to (9.7 ± 0.4 fl vs. 7.4 ± 0.1 fl; P =000). The mean PDW was significantly higher in Type 2 diabetic group as compared to the non-diabetic group (11.7± 0.4 fl vs 9.3± 0.1 fl P = 0.000). Among the Type 2 diabetic patients, MPV and PDW were significantly higher in Type 2 diabetic obese group as compared with a non-obese group (9.8± 0.5fl vs. 8.4± 0.2 fl; P= 0.000) and (11.8±0.4 vs. 10.4±0.3fl; P= 0.000) respectively.

Conclusion: Sudanese type 2 diabetic obese individuals manifest evidence of high platelet reactivity which may further subsequently increase their risk of cardiovascular complications.

Keywords


Obesity; Mean Platelet Volume (MPV); Platelet Distribution Width (PDW); platelet count; type 2 diabetes mellitus; cardiovascular complications

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References


WHO fact sheets. Obesity and overweight. Accessed from http://www.who.int/news-room/fact-sheets/ detail/obesity-and-overweight (accessed 31 may 2018).

Alwan AD, Galea G, Stuckler D. Development at risk: Addressing noncommunicable diseases at the united nations high-level meeting. Bulletin of the World Health Organization. 2011, 89:546-546A

Audureau E PJ, Coste J. Gender-Related Differential Effects of Obesity on Health-Related Quality of Life via Obesity-Related Comorbidities. Circ Cardiovasc Qual Outcomes. 2016;9(3):246-256.

Berg AH, Scherer PE. Adipose tissue, inflammation, and cardiovascular disease. Circulation research. 2005, 96:939-949

Trayhurn P. Hypoxia and adipose tissue function and dysfunction in obesity. Physiol. Rev. 2013, 93:1-21

Ouchi N PJ, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nature Reviews Immunology. 2011;11(2):85–97.

Shibata R, Ouchi N, Ohashi K, Murohara T. The role of adipokines in cardiovascular disease. Journal of Cardiology. 2017, 70:329-334

Kachur S, Lavie CJ, de Schutter A, Milani RV, Ventura HO. Obesity and cardiovascular diseases. Minerva Medica. 2017, 108:212-228

Damian DJ, Kimaro K, Mselle G, Kaaya R, Lyaruu I. Prevalence of overweight and obesity among type 2 diabetic patients attending diabetes clinics in northern Tanzania. BMC Research Notes. 2017, 10:515

WHO Global Strategy on Diet, Physical Activity and Health. Accessed from http://www.Who.Int/dietphysicalactivity/media/en/gsfs_obesity.Pdf (accessed 31 may 2018).

Beckman JA CM, Libby P. Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA. 2002;287(19):2570-81.,

Nesto RW, Rutter MK. Impact of the atherosclerotic process in patients with diabetes. Acta diabetologica. 2002, 39 Suppl 2: S22-28

Ali Y, Almobarak A, Awadalla H, Elmadhoun W, Ahmed M. Obesity among Sudanese adults with diabetes: A population-based survey. Ann Transl Med. 2017, 5:252

Group NRFCN-RAW. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: A pooled analysis of 2416 population-based measurement studies in 128•9 million children, adolescents, and adults. The Lancet logo. 2017, 390:2627–2642

Ulutas KT, Dokuyucu R, Sefil F, Yengil E, Sumbul AT, Rizaoglu H, Ustun I, Yula E, Sabuncu T, Gokce C. Evaluation of mean platelet volume in patients with type 2 diabetes mellitus and blood glucose regulation: A marker for atherosclerosis? International Journal of Clinical and Experimental Medicine. 2014, 7:955-961

Dindar S, Cinemre H, Sengul E, Annakkaya AN. Mean platelet volume is associated with glycaemic control and retinopathy in patients with type 2 diabetes mellitus. The West Indian Medical Journal. 2013, 62:519-523

Jindal S, Gupta S, Gupta R, Kakkar A, Singh HV, Gupta K, Singh S. Platelet indices in diabetes mellitus: Indicators of diabetic microvascular complications. Hematology (Amsterdam, Netherlands). 2011, 16:86-89

Khode V, Sindhur J, Kanbur D, Ruikar K, Nallulwar S. Mean platelet volume and other platelet volume indices in patients with stable coronary artery disease and acute myocardial infarction: A case control study. Journal of Cardiovascular Disease Research. 2012, 3:272-275

Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: A simple, practical and specific marker of activation of coagulation. Hippokratia. 2010, 14:28-32

Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, Mohler ER, Reilly MP, Berger JS. Mean platelet volume as a predictor of cardiovascular risk: A systematic review and meta-analysis. Journal of Thrombosis and Haemostasis. 2010, 8:148-156

Liang QC, Jin D, Li Y, Wang RT. Mean platelet volume and platelet distribution width in vascular dementia and alzheimer's disease. Platelets. 2014, 25:433-438

Wang R-t, Jin D, Li Y, Liang Q-c. Decreased mean platelet volume and platelet distribution width are associated with mild cognitive impairment and alzheimer's disease. J. Psychiatr. Res. 2013, 47:644-649

Arslan D, Cimen D, Guvenc O, Kaya F, Sert A, Oran B. Platelet distribution width and mean platelet volume in children with pulmonary arterial hypertension secondary to congenital heart disease with left-to-right shunt: New indices of severity? Pediatr. Cardiol. 2013, 34:1013-1016

Akbal A, Gokmen F, Gencer M, Inceer BS, Komurcu E. Mean platelet volume and platelet distribution width can be related to bone mineralization. Osteoporos. Int. 2014, 25:2291-2295

Buch A KS, Nair R, Jain A. Platelet volume indices as predictive biomarkers for diabetic complications in Type 2 diabetic patients. J Lab Physicians 2017;9:84-8.

Demirtas L, Degirmenci H, Akbas EM, Ozcicek A, Timuroglu A, Gurel A, Ozcicek F. Association of hematological indicies with diabetes, impaired glucose regulation and microvascular complications of diabetes. International Journal of Clinical and Experimental Medicine. 2015, 8:11420-11427

Yilmaz T, Yilmaz A. Relationship between altered platelet morphological parameters and retinopathy in patients with type 2 diabetes mellitus. Journal of Ophthalmology. 2016, 2016:9213623

Demirtunc R, Duman D, Basar M, Bilgi M, Teomete M, Garip T. The relationship between glycemic control and platelet activity in type 2 diabetes mellitus. J. Diabetes Complications. 2009, 23:89-94

Hou J, Liu C, Yao P, Chen W, He M, Wang Y, Liang Y, Miao X, Wei S, Xu T, Fang W, Zhu J, Li X, Hu FB, Wu T, Yang H, Yuan J. Association of adiposity indices with platelet distribution width and mean platelet volume in chinese adults. PLoS ONE. 2015, 10

Coban E. OM, Yazicioglu G., Akcit F. The mean platelet volume in patients with obesity. International Journal of Clinical Practice. 2005, 59:981-982

Riyahi N, Tohit ERM, Thambiah SC, Ibrahim Z. Platelet-related cytokines among normal body mass index, overweight, and obese malaysians. Asia Pacific journal of clinical nutrition. 2018, 27:182-188

A.V.Hoffbrand J EpapAM, Essential Haematology , 6th edition 2004 . chapter 24: pages 315-320.,

Farias MG SE, Dal BoS , de Castro SM , Definition of reference ranges for the platelets distribution width (PDW) : alocal need . Clin Chem Lab Med. 2010 ; 48 (2):255-257 .

Unubol M, Ayhan M, Guney E. The relationship between mean platelet volume with microalbuminuria and glycemic control in patients with type ii diabetes mellitus. Platelets. 2012, 23:475-480

Lippi G, Salvagno GL, Nouvenne A, Meschi T, Borghi L, Targher G. The mean platelet volume is significantly associated with higher glycated hemoglobin in a large population of unselected outpatients. Primary Care Diabetes. 2015, 9:226-230

Samocha-Bonet D, Justo D, Rogowski O, Saar N, Abu-Abeid S, Shenkerman G, Shapira I, Berliner S, Tomer A. Platelet counts and platelet activation markers in obese subjects. Mediators Inflamm. 2008,

Ferroni P BS, Falco A, Davi G. Platelet activation in type 2 diabetes mellitus. Journal of thrombosis and haemostasis : JTH. 2004;2(8):1282-91.,

Gresele P, Marzotti S, Guglielmini G, Momi S, Giannini S, Minuz P, Lucidi P, Bolli GB. Hyperglycemia-induced platelet activation in type 2 diabetes is resistant to aspirin but not to a nitric oxide-donating agent. Diabetes care. 2010, 33:1262-1268

Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: A link between thrombosis and inflammation? Curr. Pharm. Des. 2011, 17:47-58

Rechcinski T, Jasinska A, Forys J, Krzeminska-Pakula M, Wierzbowska-Drabik K, Plewka M, Peruga JZ, Kasprzak JD. Prognostic value of platelet indices after acute myocardial infarction treated with primary percutaneous coronary intervention. Cardiology Journal. 2013, 20:491-498

Pate A, Baltazar GA, Labana S, Bhagat T, Kim J, Chendrasekhar A. Systemic inflammatory response syndrome and platelet count ≥250×10(9) are associated with venous thromboembolic disease. International Journal of General Medicine. 2015, 8:37-40

K. El-Garf HM, Y. Farag, L. Rasheed, A. El-Garf. Mean platelet volume is a marker of inflammation but not a marker of disease activity in children with juvenile sle. Egyptian Rheumatol. 2016, 38 35-39

Larsen SB GE, Hvas AM, Kristensen SD. Platelet turnover in stable coronary artery disease – influence of thrombopoietin and low-grade inflammation. PLoS ONE. 2014, 9:e85566.

Coban E, Ozdogan M, Yazicioglu G, Akcit F. The mean platelet volume in patients with obesity. Int J Clin Pract. 2005, 59:981-982

Coban E, Yilmaz A, Sari R. The effect of weight loss on the mean platelet volume in obese patients. Platelets. 2007, 18:212-216

Kutlucan A, Bulur S, Kr S, Bulur S, Önder E, Aslantas Y, Ekinözü I, Aydn Y, Özhan H. The relationship between mean platelet volume with metabolic syndrome in obese individuals. Blood Coagulation & Fibrinolysis. 2012, 23:388-390

Furuncuoğlu Y TS, Dogan AN, Cakar S, Tulgar YK, Cakiroglu B. How obesity affects the neutrophil/lymphocyte and platelet/lymphocyte ratio, systemic immune-inflammatory index and platelet indices: A retrospective study. Eur Rev Med Pharmacol Sci. 2016 20:1300-1306


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