Cover Image

CAM5.2 Expression in Metastatic Tumours of CNS: A Diagnostic Tool

S K Mathur, rama goyal, Sumiti Gupta, Sanjay Kumar, Rahul Goyal, Nisha Marwah, Sonia Chhabra

Abstract


Introduction: Secondary tumours or metastases account for more than half of all brain tumours in adults. Central nervous system is most commonly a target of metastatic dissemination. The judicious use of  selected immunostains is unquestionably helpful in diagnostically challenging cases. CAM 5.2 being highly specific, is emerging as a specific marker to diagnose metastatic carcinoma.

Presentation of case: Total six metastatic tumours were studied using CAM5.2. Histopathological sections of brain tissue were stained by routine hematoxylin and eosin (H&E) as per standard technique. Representative sections were subjected to immunohistochemical staining with CAM 5.2. Skin biopsy act as a positive control for cytokeratin.

All of the 6 cases showed positivity for CAM 5.2. CAM5.2 expression in metastatic tumours was statistically significant (sensitivity 100% & 100% specificity).

Conclusion: We conclude in our study that CAM5.2 was significantly associated with metastatic tumours, as they were positive using this specific marker.


Keywords


CAM5.2; Metastatic CNS tumours; Cytokeratin

Full Text:

PDF

References


Munshi A, Jalali R. Therapy for Glioma: Indian perspective. Indian J Cancer. 2009, 46:127-131

Diagnostics of central nervous system metastatic disease. Available from: URL:http://www.onk.ns.ac.rs/archive/vol14/PDF.

Biernat W. Metastatic tumours of the central nervous system a pathological approach. Folia Neuropathol. 2009, 47:228-233

Roy R, Sarkar C. Some recent advances in neuro-oncology with particular reference to newer techniques for diagnosis and prognostication. Indian J Pathol Microbiol. 1990, 33:195-209

Listrom MB, Dalton LW. Comparison of keratin monoclonal antibodies MAK-6, AE1:AE3, and CAM5.2. Am J Clin Pathol. 1987, 88:297-301

Takei H, Bhattacharjee MB, Rivera A, Dancer Y, Powell SZ. New immunohistochemical markers in the evaluation of central nervous system tumors. Arch Pathol Lab Med. 2007, 131:234-241

Ironside JW, Moss TH, Louis DN, Lowe JS, Weller RO. An introduction to tumours of the nervous system. In: Diagnostic pathology of nervous system tumours. Ist ed. Churchill Livingstone; 2002. p. 1-16

David OH, Prayson RA. Evaluation of epithelial and keratin markers in glioblastoma multiforme. Arch Pathol Lab Med. 1999, 123:917-920

Pavlidis N, Briasoulis E, Hainsworth J et al. Diagnostic and therapeutic management of cancer of an unknown primary. Eur J Cancer. 2003, 39:1990-2005

Perry A, Parisi JE, Kurtin PJ. Metastatic adenocarcinoma to the brain: an immunohistochemical approach. Hum Pathol. 1997, 28:938-943

Murakata LA, Ishak KG, Nzaeko UC. Clear cell carcinoma of the liver: a comparative immunohistochemical study with renal clear cell carcinoma. Mod Pathol. 2000, 13:874-881

Roy R, Sarkar C. Some recent advances in neuro-oncology with particular reference to newer techniques for diagnosis and prognostication. Indian J PatholMicrobiol. 1990, 33:195-209


Refbacks

  • There are currently no refbacks.


AJMCR (ISSN 2574-5085)Copyright © 2012-2021. All rights reserved. Published by Ivy Union Publishing, 3204 Valley Rush Dr, Apex, North Carolina 27502, United States